4TMT
Translation initiation factor eIF5B (517-858) mutant D533A from C. thermophilum, bound to GTPgammaS
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue GSP A 901 |
| Chain | Residue |
| A | ALA533 |
| A | THR557 |
| A | GLY597 |
| A | ASN648 |
| A | LYS649 |
| A | ASP651 |
| A | ARG652 |
| A | SER716 |
| A | ALA717 |
| A | HIS718 |
| A | MG902 |
| A | THR534 |
| A | HOH1064 |
| A | HOH1065 |
| A | HOH1070 |
| A | HOH1232 |
| A | GLY535 |
| A | LYS536 |
| A | THR537 |
| A | LYS538 |
| A | GLN549 |
| A | GLY555 |
| A | ILE556 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 902 |
| Chain | Residue |
| A | THR537 |
| A | THR557 |
| A | GSP901 |
| A | HOH1064 |
| A | HOH1065 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 903 |
| Chain | Residue |
| A | GLY694 |
| A | PHE695 |
| A | ASN696 |
| A | ARG708 |
| A | TYR709 |
| A | HOH1002 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 904 |
| Chain | Residue |
| A | LYS542 |
| A | ILE543 |
| A | GLN545 |
| A | LYS573 |
| A | ASN661 |
| A | HOH1024 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 905 |
| Chain | Residue |
| A | LYS704 |
| A | ASN705 |
| A | PHE706 |
| A | ALA707 |
| A | HOH1013 |
| A | HOH1254 |
| A | HOH1304 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 906 |
| Chain | Residue |
| A | ILE621 |
| A | MET622 |
| A | HIS623 |
| A | ARG682 |
| A | GLN685 |
| A | VAL686 |
| A | GLN689 |
| A | HOH1228 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 907 |
| Chain | Residue |
| A | GLU599 |
| A | SER600 |
| A | SER602 |
| A | HOH1200 |
| A | HOH1241 |
| B | LYS571 |
| B | HOH1176 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 908 |
| Chain | Residue |
| A | PRO642 |
| A | PHE643 |
| A | ARG737 |
| A | HOH1267 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue DTT A 909 |
| Chain | Residue |
| A | CYS734 |
| A | GLN735 |
| A | GLU736 |
| A | MET738 |
| A | SER740 |
| A | MET743 |
| A | HOH1202 |
| A | HOH1293 |
| site_id | AD1 |
| Number of Residues | 26 |
| Details | binding site for residue GSP B 901 |
| Chain | Residue |
| B | HOH1237 |
| B | VAL532 |
| B | ALA533 |
| B | THR534 |
| B | GLY535 |
| B | LYS536 |
| B | THR537 |
| B | LYS538 |
| B | GLN549 |
| B | GLY555 |
| B | ILE556 |
| B | THR557 |
| B | GLY597 |
| B | ASN648 |
| B | LYS649 |
| B | ASP651 |
| B | ARG652 |
| B | SER716 |
| B | ALA717 |
| B | HIS718 |
| B | MG902 |
| B | HOH1071 |
| B | HOH1072 |
| B | HOH1086 |
| B | HOH1203 |
| B | HOH1214 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 902 |
| Chain | Residue |
| B | THR537 |
| B | THR557 |
| B | GSP901 |
| B | HOH1071 |
| B | HOH1072 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 903 |
| Chain | Residue |
| B | LEU521 |
| B | EDO904 |
| B | HOH1095 |
| B | HOH1278 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 904 |
| Chain | Residue |
| B | ASP519 |
| B | EDO903 |
| B | HOH1095 |
| B | HOH1278 |
| B | HOH1313 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 905 |
| Chain | Residue |
| B | ILE560 |
| B | GLU754 |
| B | ASP766 |
| B | ARG806 |
| B | HOH1098 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 906 |
| Chain | Residue |
| B | PRO799 |
| B | GLU804 |
| B | LEU805 |
| B | ILE807 |
| B | GLY809 |
| B | GLN810 |
| B | TYR811 |
| B | HOH1141 |
| B | HOH1354 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 907 |
| Chain | Residue |
| B | LYS687 |
| B | ASN696 |
| B | SER697 |
| B | GLU698 |
| B | HOH1090 |
| B | HOH1213 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 908 |
| Chain | Residue |
| B | VAL577 |
| B | ASN578 |
| B | LYS579 |
| B | ASP580 |
| B | HOH1183 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 909 |
| Chain | Residue |
| B | LEU748 |
| B | GLY772 |
| B | ILE773 |
| B | ARG775 |
| B | HOH1167 |
| B | HOH1358 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue ACY B 910 |
| Chain | Residue |
| B | TYR564 |
| B | PRO801 |
| B | GLN821 |
| B | HOH1100 |
| B | HOH1252 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 911 |
| Chain | Residue |
| B | ILE543 |
| B | ARG544 |
| B | GLN545 |
| B | LYS573 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 442 |
| Details | Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24686316","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TMV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
