4TKX

Structure of Protease

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0006508	biological_process	proteolysis
L	0008233	molecular_function	peptidase activity
L	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 L 701

Chain	Residue
L	GLU547
L	ARG597
L	LYS601
L	ASN670
L	HOH801
L	HOH839
L	HOH1234

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 L 702

Chain	Residue
L	THR426
L	EDO716
L	PRO424
L	TYR425

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 L 703

Chain	Residue
L	ASP229
L	VAL230
L	HIS566
L	ASN569
L	HOH1266

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 L 704

Chain	Residue
L	GLY427
L	CYS428
L	TYR429
L	SER430
L	EDO709
L	EDO716

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NA L 705

Chain	Residue
L	ALA543
L	THR544
L	LEU546
L	SER549
L	TYR550
L	ASN551

---

site_id	AC6
Number of Residues	6
Details	binding site for residue NA L 706

Chain	Residue
L	TYR402
L	VAL521
L	THR536
L	SER537
L	ASP542
L	HOH963

---

site_id	AC7
Number of Residues	6
Details	binding site for residue K L 707

Chain	Residue
L	ASP388
L	ASP388
L	HIS444
L	HIS444
L	HOH805
L	HOH805

---

site_id	AC8
Number of Residues	6
Details	binding site for residue ACT L 708

Chain	Residue
L	GLU279
L	SER286
L	PHE290
L	HOH804
L	HOH806
L	HOH822

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO L 709

Chain	Residue
L	TYR429
L	ASN433
L	GLN459
L	SO4704
L	HOH972

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO L 710

Chain	Residue
L	GLU356
L	HOH990
L	HOH1217

---

site_id	AD2
Number of Residues	8
Details	binding site for residue EDO L 711

Chain	Residue
L	ASN524
L	VAL529
L	PRO531
L	THR532
L	HOH934
L	HOH1074
L	HOH1102
L	HOH1192

---

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO L 712

Chain	Residue
L	HIS412
L	ARG597
L	MET599
L	LYS601
L	ASN670
L	HOH807
L	HOH837

---

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO L 713

Chain	Residue
L	HIS412
L	THR604
L	GLN621
L	ALA622
L	HOH815
L	HOH851

---

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO L 714

Chain	Residue
L	SER537
L	HIS566
L	HOH1004
L	HOH1273

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO L 715

Chain	Residue
L	ASP416
L	TYR418
L	HOH1009
L	HOH1242

---

site_id	AD7
Number of Residues	7
Details	binding site for residue EDO L 716

Chain	Residue
L	THR426
L	CYS428
L	PRO453
L	SO4702
L	SO4704
L	HOH1083
L	HOH1122

---

site_id	AD8
Number of Residues	3
Details	binding site for residue EDO L 717

Chain	Residue
L	ASP236
L	LEU237
L	TYR238

---

site_id	AD9
Number of Residues	7
Details	binding site for residue EDO L 718

Chain	Residue
L	HOH886
L	ASP362
L	MET366
L	LYS466
L	ASP467
L	TYR469
L	GLU498

---

site_id	AE1
Number of Residues	6
Details	binding site for residue PB L 719

Chain	Residue
L	ASP313
L	PHE482
L	GLU491
L	HOH1203
L	HOH1238
L	HOH1275

---

site_id	AE2
Number of Residues	16
Details	binding site for residue TCK L 720

Chain	Residue
L	SER390
L	TRP391
L	THR442
L	ALA443
L	HIS444
L	GLY445
L	ASN475
L	CYS477
L	ASN510
L	SER511
L	TYR512
L	TRP513
L	ASP516
L	HOH805
L	HOH856
L	HOH949

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:25266723

Chain	Residue	Details
L	HIS444

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:25266723

Chain	Residue	Details
L	CYS477

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:25266723, ECO:0007744|PDB:4RBM

Chain	Residue	Details
L	ASP313
L	ASP337
L	ASP339
L	PHE341
L	GLU343
L	PHE482
L	GLU491

---