4SGB

STRUCTURE OF THE COMPLEX OF STREPTOMYCES GRISEUS PROTEINASE B AND POLYPEPTIDE CHYMOTRYPSIN INHIBITOR-1 FROM RUSSET BURBANK POTATO TUBERS AT 2.1 ANGSTROMS RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
I	0004867	molecular_function	serine-type endopeptidase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 244

Chain	Residue
E	ASN67
E	SER68
E	ALA69
E	HOH304
E	HOH312

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 245

Chain	Residue
E	ARG139
E	GLY156
E	THR157
E	HOH252

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 8

Chain	Residue
E	GLY120
E	ASP120
E	ILE121
E	TYR243
E	HOH250
I	ARG51

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAGHC

Chain	Residue	Details
E	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. CAepGDSGGPLY

Chain	Residue	Details
E	CYS189-TYR200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Reactive bond for chymotrypsin => ECO:0000305

Chain	Residue	Details
I	LEU38
E	ASP102
E	SER195

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1ssx

Chain	Residue	Details
E	ASP102
E	SER195
E	GLY193
E	HIS57

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site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 1ssx

Chain	Residue	Details
E	ASP102
E	SER195
E	GLY193
E	HIS57
E	SER214

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site_id	MCSA1
Number of Residues	5
Details	M-CSA 608

Chain	Residue	Details
E	HIS57	proton acceptor, proton donor
E	ASP102	electrostatic stabiliser
E	GLY193	electrostatic stabiliser
E	SER195	nucleofuge, nucleophile, proton acceptor, proton donor
E	SER214	electrostatic stabiliser

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