4SGA

STRUCTURES OF PRODUCT AND INHIBITOR COMPLEXES OF STREPTOMYCES GRISEUS PROTEASE A AT 1.8 ANGSTROMS RESOLUTION. A MODEL FOR SERINE PROTEASE CATALYSIS

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR CHAIN P OF TETRAPEPTIDE ACE-PRO-ALA-PRO-PHE

Chain	Residue
E	HIS57
E	SER195
E	SER214
E	GLY215
E	GLY216
E	HOH391
P	HOH356
P	HOH357
E	VAL169
E	ASN170
E	TYR171
E	ALA192
E	GLN192
E	PRO192
E	GLY193
E	ASP194

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAGHC

Chain	Residue	Details
E	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. CAqpGDSGGSLF

Chain	Residue	Details
E	CYS191-PHE200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
E	HIS57
E	ASP102
E	SER195

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1ssx

Chain	Residue	Details
E	ASP102
E	SER195
E	GLY193
E	HIS57
E	SER214

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1ssx

Chain	Residue	Details
E	ASP102
E	SER195
E	GLY193
E	HIS57

---