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4S30

ERK2 intrinsically active mutant (I84A)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0000166molecular_functionnucleotide binding
A0001784molecular_functionphosphotyrosine residue binding
A0003690molecular_functiondouble-stranded DNA binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004707molecular_functionMAP kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0005925cellular_componentfocal adhesion
A0006357biological_processregulation of transcription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007049biological_processcell cycle
A0007166biological_processcell surface receptor signaling pathway
A0007507biological_processheart development
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
A0009636biological_processresponse to toxic substance
A0009887biological_processanimal organ morphogenesis
A0010759biological_processpositive regulation of macrophage chemotaxis
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0014032biological_processneural crest cell development
A0014044biological_processSchwann cell development
A0014069cellular_componentpostsynaptic density
A0015966biological_processdiadenosine tetraphosphate biosynthetic process
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019233biological_processsensory perception of pain
A0019858biological_processcytosine metabolic process
A0019901molecular_functionprotein kinase binding
A0019902molecular_functionphosphatase binding
A0030278biological_processregulation of ossification
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0030521biological_processandrogen receptor signaling pathway
A0030641biological_processregulation of cellular pH
A0030878biological_processthyroid gland development
A0031143cellular_componentpseudopodium
A0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
A0031647biological_processregulation of protein stability
A0031663biological_processlipopolysaccharide-mediated signaling pathway
A0032212biological_processpositive regulation of telomere maintenance via telomerase
A0032496biological_processresponse to lipopolysaccharide
A0032839cellular_componentdendrite cytoplasm
A0032872biological_processregulation of stress-activated MAPK cascade
A0032991cellular_componentprotein-containing complex
A0033598biological_processmammary gland epithelial cell proliferation
A0034198biological_processcellular response to amino acid starvation
A0034614biological_processcellular response to reactive oxygen species
A0035094biological_processresponse to nicotine
A0035556biological_processintracellular signal transduction
A0038127biological_processERBB signaling pathway
A0038133biological_processERBB2-ERBB3 signaling pathway
A0042307biological_processpositive regulation of protein import into nucleus
A0042473biological_processouter ear morphogenesis
A0042552biological_processmyelination
A0042802molecular_functionidentical protein binding
A0043204cellular_componentperikaryon
A0043330biological_processresponse to exogenous dsRNA
A0043401biological_processsteroid hormone mediated signaling pathway
A0043627biological_processresponse to estrogen
A0045596biological_processnegative regulation of cell differentiation
A0045727biological_processpositive regulation of translation
A0045893biological_processpositive regulation of DNA-templated transcription
A0046697biological_processdecidualization
A0048009biological_processinsulin-like growth factor receptor signaling pathway
A0048538biological_processthymus development
A0050847biological_processprogesterone receptor signaling pathway
A0050852biological_processT cell receptor signaling pathway
A0050853biological_processB cell receptor signaling pathway
A0051403biological_processstress-activated MAPK cascade
A0051493biological_processregulation of cytoskeleton organization
A0060020biological_processBergmann glial cell differentiation
A0060045biological_processpositive regulation of cardiac muscle cell proliferation
A0060291biological_processlong-term synaptic potentiation
A0060324biological_processface development
A0060425biological_processlung morphogenesis
A0060440biological_processtrachea formation
A0060716biological_processlabyrinthine layer blood vessel development
A0061308biological_processcardiac neural crest cell development involved in heart development
A0070161cellular_componentanchoring junction
A0070371biological_processERK1 and ERK2 cascade
A0070849biological_processresponse to epidermal growth factor
A0071276biological_processcellular response to cadmium ion
A0071310biological_processcellular response to organic substance
A0071356biological_processcellular response to tumor necrosis factor
A0072584biological_processcaveolin-mediated endocytosis
A0072686cellular_componentmitotic spindle
A0090170biological_processregulation of Golgi inheritance
A0106310molecular_functionprotein serine kinase activity
A0120041biological_processpositive regulation of macrophage proliferation
A1904355biological_processpositive regulation of telomere capping
A2000641biological_processregulation of early endosome to late endosome transport
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGAYGMVCsAydnlnkvrv.........AIKK
ChainResidueDetails
AILE29-LYS53

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpsNLLL
ChainResidueDetails
AVAL143-LEU155

site_idPS01351
Number of Residues103
DetailsMAPK MAP kinase signature. FehqtycqrtlREikillrfrheniigandiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqilrglkyihsanvlh..........RDlKpsnlllnttC
ChainResidueDetails
APHE57-CYS159

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP147

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:8639522
ChainResidueDetails
AILE29
ALYS52

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.2
ChainResidueDetails
AALA2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by SGK1 => ECO:0000250|UniProtKB:P28482
ChainResidueDetails
ASER27

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ATHR183

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ATYR185

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000250|UniProtKB:P28482
ChainResidueDetails
ATHR188

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P28482
ChainResidueDetails
ASER244
ASER246
ASER282

217705

PDB entries from 2024-03-27

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