4S2U

Crystal structure of the Phosphorybosylpyrophosphate synthetase from E. Coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0002189	cellular_component	ribose phosphate diphosphokinase complex
A	0004749	molecular_function	ribose phosphate diphosphokinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0034214	biological_process	protein hexamerization
A	0042301	molecular_function	phosphate ion binding
A	0042802	molecular_function	identical protein binding
A	0043531	molecular_function	ADP binding
A	0044249	biological_process	cellular biosynthetic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 401

Chain	Residue
A	ASP224
A	THR225
A	THR228

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Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. CVLVDDMIDTGgT

Chain	Residue	Details
A	CYS216-THR228

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site_id	PS00114
Number of Residues	16
Details	PRPP_SYNTHASE Phosphoribosyl pyrophosphate synthase signature. DLHAeQIQGFFdvPVD

Chain	Residue	Details
A	ASP129-ASP144

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:7657655

Chain	Residue	Details
A	LYS194

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site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00583

Chain	Residue	Details
A	ASP37
A	ARG96
A	HIS131
A	ASP170
A	ARG196
A	ASP220
A	ASP224

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