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4S27

Crystal structure of Arabidopsis thaliana ThiC with bound aminoimidazole ribonucleotide, 5'-deoxyadenosine, L-methionine, Fe4S4 cluster and Fe

Functional Information from GO Data
ChainGOidnamespacecontents
A0009228biological_processthiamine biosynthetic process
A0016830molecular_functioncarbon-carbon lyase activity
A0051536molecular_functioniron-sulfur cluster binding
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SF4 A 701
ChainResidue
ACYS570
AMET572
ACYS573
ACYS578
ASER579
AMET704
ACL706

site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE AIR A 702
ChainResidue
ALEU259
ATYR286
AHIS322
ASER342
AARG343
AGLY344
AASP383
AARG386
AGLU422
AGLY423
ATYR449
ACYS483
A5AD703
AHOH878
AASN228
AMET257

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 5AD A 703
ChainResidue
AASN228
AILE229
AGLY230
AASN231
ALEU259
AARG343
AARG386
ALEU451
AGLU489
ALEU493
AMET572
AAIR702
AHOH861
AHOH862
AHOH874
AHOH920

site_idAC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE MET A 704
ChainResidue
AVAL341
AARG386
AHIS426
ALEU451
AGLU489
AHIS490
ACYS573
ASF4701
AFE2705
AHOH869
AHOH1181

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FE2 A 705
ChainResidue
AHIS426
AHIS490
AMET704
AHOH1181
AHOH1182

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 706
ChainResidue
AHIS490
ASF4701
AHOH1301

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE BU1 A 707
ChainResidue
AARG305
AARG305
AHOH865
AHOH865

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE BU1 A 708
ChainResidue
AVAL113
APRO114
APHE115
ATHR183
AARG184
AHOH824

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues11
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9A6Q5
ChainResidueDetails
AASN228
ACYS573
ACYS578
AMET257
ATYR286
AHIS322
ASER342
AASP383
AGLU422
ATYR449
ACYS570

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:24161603
ChainResidueDetails
AHIS426
AHIS490

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PDB entries from 2024-11-06

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