4RZ6
Transaldolase B E96Q F178Y from E.coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004801 | molecular_function | transaldolase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006098 | biological_process | pentose-phosphate shunt |
| A | 0009052 | biological_process | pentose-phosphate shunt, non-oxidative branch |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016744 | molecular_function | transketolase or transaldolase activity |
| B | 0004801 | molecular_function | transaldolase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006098 | biological_process | pentose-phosphate shunt |
| B | 0009052 | biological_process | pentose-phosphate shunt, non-oxidative branch |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016744 | molecular_function | transketolase or transaldolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | ARG181 |
| A | SER226 |
| A | ARG228 |
| A | HOH573 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | HOH602 |
| A | ARG92 |
| A | PHE173 |
| A | ARG241 |
| A | HOH538 |
| A | HOH540 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE P6G A 403 |
| Chain | Residue |
| A | TRP137 |
| A | GLN138 |
| A | GLU278 |
| A | PHE281 |
| A | LEU282 |
| A | HIS285 |
| A | ASN286 |
| A | CL404 |
| A | HOH578 |
| B | TYR103 |
| B | TRP137 |
| B | GLN138 |
| B | GLU278 |
| B | PHE281 |
| B | LEU282 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 404 |
| Chain | Residue |
| A | ASN286 |
| A | P6G403 |
| B | TYR103 |
| B | LEU295 |
| B | HOH518 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 401 |
| Chain | Residue |
| B | ARG92 |
| B | PHE173 |
| B | ARG241 |
| B | HOH516 |
| B | HOH550 |
| B | HOH568 |
| B | HOH662 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 402 |
| Chain | Residue |
| B | ARG181 |
| B | SER226 |
| B | ARG228 |
| B | HOH595 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 403 |
| Chain | Residue |
| A | ASN286 |
| A | HOH504 |
| B | TYR103 |
| B | ALA296 |
| B | ILE299 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 404 |
| Chain | Residue |
| B | VAL97 |
| B | SER102 |
| B | SER108 |
| B | HOH501 |
| B | HOH517 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 405 |
| Chain | Residue |
| B | ALA110 |
| B | LYS111 |
| B | HOH502 |
| B | HOH561 |
| B | HOH633 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Schiff-base intermediate with substrate","evidences":[{"source":"PubMed","id":"11298760","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 148 |
| Chain | Residue | Details |
| A | ASP17 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLN96 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | LYS132 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | THR156 | electrostatic stabiliser, hydrogen bond donor |
| A | TYR178 | steric role |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 148 |
| Chain | Residue | Details |
| B | ASP17 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | GLN96 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | LYS132 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | THR156 | electrostatic stabiliser, hydrogen bond donor |
| B | TYR178 | steric role |
