Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4RXO

The structure of GTP-bound SAMHD1

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 701

Chain	Residue
A	ARG164
A	HIS167
A	HIS206
A	ASP207
A	ASP311
A	PO4702

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 702

Chain	Residue
A	HIS210
A	HIS215
A	HIS233
A	ASP311
A	TYR315
A	ZN701
A	HOH847
A	ARG164
A	HIS167
A	ASP207

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GTP B 801

Chain	Residue
A	TYR155
A	VAL156
A	VAL378
A	ARG451
A	LEU453
B	LYS116
B	VAL117
B	ILE118
B	ASP137
B	GLN142
B	ARG145
B	PHE165
B	HOH972

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 802

Chain	Residue
B	HIS167
B	HIS206
B	ASP207
B	ASP311
B	PO4804

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GTP B 803

Chain	Residue
A	LYS116
A	VAL117
A	ILE118
A	ASP137
A	GLN142
A	ARG145
A	PHE165
B	TYR155
B	VAL156
B	ARG451
B	LEU453
B	LYS455
B	HOH936
B	HOH975

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 B 804

Chain	Residue
B	ARG164
B	HIS167
B	ASP207
B	HIS210
B	HIS215
B	HIS233
B	ASP311
B	ZN802
B	HOH930

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN C 701

Chain	Residue
C	ARG164
C	HIS167
C	HIS206
C	ASP207
C	ASP311
C	PO4703

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GTP C 702

Chain	Residue
C	TYR155
C	VAL156
C	VAL378
C	ARG451
C	HOH830
C	HOH856
C	HOH857
C	HOH861
D	LYS116
D	VAL117
D	ILE118
D	ASP137
D	GLN142
D	ARG145
D	PHE165
D	HOH834

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 C 703

Chain	Residue
C	ARG164
C	HIS167
C	ASP207
C	HIS210
C	HIS215
C	HIS233
C	ASP311
C	ZN701
C	HOH863

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 701

Chain	Residue
D	HIS167
D	HIS206
D	ASP207
D	ASP311
D	PO4703

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GTP D 702

Chain	Residue
C	PHE165
D	TYR155
D	VAL156
D	VAL378
D	ARG451
D	LEU453
C	LYS116
C	VAL117
C	ILE118
C	ASP137
C	GLN142
C	ARG145

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 D 703

Chain	Residue
D	ARG164
D	HIS167
D	ASP207
D	HIS210
D	HIS215
D	HIS233
D	ASP311
D	ZN701
D	HOH846

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"22056990","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24141705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BZB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"description":"in chain C","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"24141705","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"description":"in chain C","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)