4RWQ

Crystal structure of the apo-state of porcine OAS1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001730	molecular_function	2'-5'-oligoadenylate synthetase activity
A	0002376	biological_process	immune system process
A	0003723	molecular_function	RNA binding
A	0003725	molecular_function	double-stranded RNA binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
A	0060337	biological_process	type I interferon-mediated signaling pathway
A	0060700	biological_process	regulation of ribonuclease activity
A	0070106	biological_process	interleukin-27-mediated signaling pathway
A	0140374	biological_process	antiviral innate immune response
B	0000166	molecular_function	nucleotide binding
B	0001730	molecular_function	2'-5'-oligoadenylate synthetase activity
B	0002376	biological_process	immune system process
B	0003723	molecular_function	RNA binding
B	0003725	molecular_function	double-stranded RNA binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0045071	biological_process	negative regulation of viral genome replication
B	0045087	biological_process	innate immune response
B	0046872	molecular_function	metal ion binding
B	0051607	biological_process	defense response to virus
B	0060337	biological_process	type I interferon-mediated signaling pathway
B	0060700	biological_process	regulation of ribonuclease activity
B	0070106	biological_process	interleukin-27-mediated signaling pathway
B	0140374	biological_process	antiviral innate immune response

Functional Information from PROSITE/UniProt

site_id	PS00832
Number of Residues	20
Details	25A_SYNTH_1 2'-5'-oligoadenylate synthases signature 1. GSsGKgTtLRgrsDaDLVvF

Chain	Residue	Details
A	GLY61-PHE80

---

site_id	PS00833
Number of Residues	11
Details	25A_SYNTH_2 2'-5'-oligoadenylate synthases signature 2. RPVILDPaDPT

Chain	Residue	Details
A	ARG295-THR305

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	114
Details	Region: {"description":"Interaction with dsRNA","evidences":[{"source":"UniProtKB","id":"P00973","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00973","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18604630","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14636576","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Interaction with dsRNA","evidences":[{"source":"UniProtKB","id":"P00973","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---