4RV4

2.65 Angstrom Resolution Crystal Structure of an orotate phosphoribosyltransferase from Bacillus anthracis str. 'Ames Ancestor' in complex with 5-phospho-alpha-D-ribosyl diphosphate (PRPP)

Replaces:  3OSC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004588	molecular_function	orotate phosphoribosyltransferase activity
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006222	biological_process	UMP biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004588	molecular_function	orotate phosphoribosyltransferase activity
B	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006222	biological_process	UMP biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004588	molecular_function	orotate phosphoribosyltransferase activity
C	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006222	biological_process	UMP biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VVVVEDLISTGgS

Chain	Residue	Details
A	VAL116-SER128

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01208

Chain	Residue	Details
A	ARG94
C	LYS98
C	HIS100
C	SER124
A	LYS98
A	HIS100
A	SER124
B	ARG94
B	LYS98
B	HIS100
B	SER124
C	ARG94

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01208

Chain	Residue	Details
A	GLU120
B	GLU120
C	GLU120

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