4RUK
crystal structure of Phosphoapantetheine adenylyltransferase PPAT/CoaD with CoA and pyrophosphate from Pseudomonas aeruginosa
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008771 | molecular_function | [citrate (pro-3S)-lyase] ligase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0015937 | biological_process | coenzyme A biosynthetic process |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008771 | molecular_function | [citrate (pro-3S)-lyase] ligase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0015937 | biological_process | coenzyme A biosynthetic process |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008771 | molecular_function | [citrate (pro-3S)-lyase] ligase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0015937 | biological_process | coenzyme A biosynthetic process |
| C | 0016779 | molecular_function | nucleotidyltransferase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008771 | molecular_function | [citrate (pro-3S)-lyase] ligase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0015937 | biological_process | coenzyme A biosynthetic process |
| D | 0016779 | molecular_function | nucleotidyltransferase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0008771 | molecular_function | [citrate (pro-3S)-lyase] ligase activity |
| E | 0009058 | biological_process | biosynthetic process |
| E | 0015937 | biological_process | coenzyme A biosynthetic process |
| E | 0016779 | molecular_function | nucleotidyltransferase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0008771 | molecular_function | [citrate (pro-3S)-lyase] ligase activity |
| F | 0009058 | biological_process | biosynthetic process |
| F | 0015937 | biological_process | coenzyme A biosynthetic process |
| F | 0016779 | molecular_function | nucleotidyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE COA A 201 |
| Chain | Residue |
| A | PRO7 |
| A | TYR97 |
| A | LEU101 |
| A | SER127 |
| A | SER128 |
| A | THR129 |
| A | ARG132 |
| A | DMS204 |
| A | DMS205 |
| A | ACT208 |
| A | HOH320 |
| A | GLY8 |
| A | HOH321 |
| F | LEU130 |
| F | GLU133 |
| A | THR9 |
| A | HIS17 |
| A | LYS41 |
| A | LEU72 |
| A | LEU73 |
| A | ARG87 |
| A | ARG90 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS A 202 |
| Chain | Residue |
| A | LYS15 |
| A | ASP19 |
| A | TYR123 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS A 203 |
| Chain | Residue |
| A | ALA135 |
| A | GLY138 |
| A | GLY139 |
| A | ASP140 |
| A | ILE141 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS A 204 |
| Chain | Residue |
| A | ALA36 |
| A | ALA37 |
| A | SER38 |
| A | PHE69 |
| A | THR71 |
| A | COA201 |
| A | HOH317 |
| F | LEU137 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 205 |
| Chain | Residue |
| A | GLY16 |
| A | ARG90 |
| A | COA201 |
| A | ACT208 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT A 206 |
| Chain | Residue |
| A | ASP140 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 208 |
| Chain | Residue |
| A | TYR6 |
| A | PRO7 |
| A | ARG87 |
| A | GLY88 |
| A | COA201 |
| A | DMS205 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE COA B 201 |
| Chain | Residue |
| B | PRO7 |
| B | GLY8 |
| B | THR9 |
| B | HIS17 |
| B | ALA36 |
| B | LYS41 |
| B | PHE69 |
| B | THR71 |
| B | LEU72 |
| B | LEU73 |
| B | ARG87 |
| B | TYR97 |
| B | LEU101 |
| B | SER127 |
| B | SER128 |
| B | THR129 |
| B | ARG132 |
| B | HOH306 |
| E | GLU133 |
| E | LEU137 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT B 202 |
| Chain | Residue |
| B | SER25 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT B 204 |
| Chain | Residue |
| B | VAL67 |
| B | GLY68 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT B 205 |
| Chain | Residue |
| B | GLN55 |
| B | GLU65 |
| B | VAL66 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT B 206 |
| Chain | Residue |
| B | GLU65 |
| B | VAL67 |
| B | GLN80 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 207 |
| Chain | Residue |
| B | ASP140 |
| B | ILE141 |
| B | SER142 |
| B | LYS143 |
| B | PHE144 |
| site_id | BC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE COA C 201 |
| Chain | Residue |
| A | LEU130 |
| A | GLU133 |
| A | LEU137 |
| C | GLY8 |
| C | THR9 |
| C | LYS41 |
| C | PHE69 |
| C | LEU72 |
| C | LEU73 |
| C | ARG87 |
| C | TYR97 |
| C | LEU101 |
| C | SER127 |
| C | SER128 |
| C | THR129 |
| C | HOH305 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT C 202 |
| Chain | Residue |
| C | LYS81 |
| C | ALA82 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT C 203 |
| Chain | Residue |
| C | LYS15 |
| C | GLY18 |
| C | ASP19 |
| C | HOH317 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT C 204 |
| Chain | Residue |
| C | GLU65 |
| C | GLN80 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT C 205 |
| Chain | Residue |
| C | ASN83 |
| C | ASP111 |
| D | ARG26 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 206 |
| Chain | Residue |
| C | TYR6 |
| C | HIS17 |
| C | ARG87 |
| C | GLY88 |
| C | ARG90 |
| site_id | CC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE COA D 201 |
| Chain | Residue |
| B | GLU133 |
| B | LEU137 |
| D | PRO7 |
| D | GLY8 |
| D | THR9 |
| D | LYS41 |
| D | LEU72 |
| D | LEU73 |
| D | ARG87 |
| D | ARG90 |
| D | SER93 |
| D | ASP94 |
| D | TYR97 |
| D | LEU101 |
| D | SER127 |
| D | SER128 |
| D | THR129 |
| D | DMS203 |
| D | HOH318 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE POP D 202 |
| Chain | Residue |
| D | TYR6 |
| D | HIS17 |
| D | LEU20 |
| D | ARG87 |
| D | GLY88 |
| D | ARG90 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS D 203 |
| Chain | Residue |
| B | LEU137 |
| D | ALA36 |
| D | ALA37 |
| D | SER38 |
| D | PHE69 |
| D | SER70 |
| D | THR71 |
| D | COA201 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS D 204 |
| Chain | Residue |
| D | GLY68 |
| D | PHE69 |
| D | SER70 |
| D | THR71 |
| D | FMT205 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT D 205 |
| Chain | Residue |
| D | DMS204 |
| site_id | CC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL D 206 |
| Chain | Residue |
| D | LYS40 |
| D | LYS41 |
| site_id | CC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT E 201 |
| Chain | Residue |
| E | ARG132 |
| site_id | CC9 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE COA E 202 |
| Chain | Residue |
| D | LEU130 |
| D | ILE134 |
| D | LEU137 |
| E | PRO7 |
| E | GLY8 |
| E | THR9 |
| E | PHE10 |
| E | HIS17 |
| E | ALA36 |
| E | SER38 |
| E | LYS41 |
| E | PHE69 |
| E | SER70 |
| E | THR71 |
| E | LEU73 |
| E | ARG87 |
| E | TYR97 |
| E | LEU101 |
| E | SER127 |
| E | SER128 |
| E | THR129 |
| E | CA203 |
| E | ACT206 |
| E | HOH303 |
| E | HOH305 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA E 203 |
| Chain | Residue |
| E | HIS17 |
| E | ARG90 |
| E | SER128 |
| E | COA202 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS E 204 |
| Chain | Residue |
| E | LYS15 |
| E | GLY18 |
| E | ASP19 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT E 205 |
| Chain | Residue |
| E | SER25 |
| E | ARG26 |
| E | LEU27 |
| E | PHE28 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT E 206 |
| Chain | Residue |
| E | TYR6 |
| E | ARG87 |
| E | GLY88 |
| E | ARG90 |
| E | COA202 |
| site_id | DC5 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE COA F 201 |
| Chain | Residue |
| C | LEU130 |
| C | LEU137 |
| F | PRO7 |
| F | GLY8 |
| F | THR9 |
| F | PHE10 |
| F | HIS17 |
| F | ALA36 |
| F | ALA37 |
| F | SER38 |
| F | LYS41 |
| F | PHE69 |
| F | SER70 |
| F | THR71 |
| F | LEU72 |
| F | LEU73 |
| F | ARG87 |
| F | TYR97 |
| F | LEU101 |
| F | SER127 |
| F | SER128 |
| F | THR129 |
| F | CA203 |
| F | ACT206 |
| F | HOH305 |
| F | HOH310 |
| F | HOH318 |
| site_id | DC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE POP F 202 |
| Chain | Residue |
| F | LYS15 |
| F | GLY18 |
| F | ASP19 |
| F | GLU22 |
| F | VAL57 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA F 203 |
| Chain | Residue |
| F | HIS17 |
| F | SER128 |
| F | COA201 |
| F | HOH314 |
| site_id | DC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS F 204 |
| Chain | Residue |
| B | ARG26 |
| F | ASN83 |
| F | ASP111 |
| site_id | DC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DMS F 205 |
| Chain | Residue |
| F | MET1 |
| F | ARG3 |
| F | LYS81 |
| site_id | EC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT F 206 |
| Chain | Residue |
| F | TYR6 |
| F | ARG87 |
| F | GLY88 |
| F | ARG90 |
| F | COA201 |
