4RQU

Alcohol Dehydrogenase crystal structure in complex with NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001666	biological_process	response to hypoxia
A	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006970	biological_process	response to osmotic stress
A	0008270	molecular_function	zinc ion binding
A	0009409	biological_process	response to cold
A	0009413	biological_process	response to flooding
A	0009414	biological_process	response to water deprivation
A	0009651	biological_process	response to salt stress
A	0009737	biological_process	response to abscisic acid
A	0009744	biological_process	response to sucrose
A	0016491	molecular_function	oxidoreductase activity
A	0031000	biological_process	response to caffeine
A	0032355	biological_process	response to estradiol
A	0042542	biological_process	response to hydrogen peroxide
A	0042803	molecular_function	protein homodimerization activity
A	0046294	biological_process	formaldehyde catabolic process
A	0046872	molecular_function	metal ion binding
A	0051903	molecular_function	S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
A	0071456	biological_process	cellular response to hypoxia
A	0120542	molecular_function	ethanol dehydrogenase (NAD+) activity
A	1900039	biological_process	positive regulation of cellular response to hypoxia
B	0000166	molecular_function	nucleotide binding
B	0001666	biological_process	response to hypoxia
B	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006970	biological_process	response to osmotic stress
B	0008270	molecular_function	zinc ion binding
B	0009409	biological_process	response to cold
B	0009413	biological_process	response to flooding
B	0009414	biological_process	response to water deprivation
B	0009651	biological_process	response to salt stress
B	0009737	biological_process	response to abscisic acid
B	0009744	biological_process	response to sucrose
B	0016491	molecular_function	oxidoreductase activity
B	0031000	biological_process	response to caffeine
B	0032355	biological_process	response to estradiol
B	0042542	biological_process	response to hydrogen peroxide
B	0042803	molecular_function	protein homodimerization activity
B	0046294	biological_process	formaldehyde catabolic process
B	0046872	molecular_function	metal ion binding
B	0051903	molecular_function	S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
B	0071456	biological_process	cellular response to hypoxia
B	0120542	molecular_function	ethanol dehydrogenase (NAD+) activity
B	1900039	biological_process	positive regulation of cellular response to hypoxia

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	CYS99
A	CYS102
A	CYS105
A	CYS113

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	CYS47
A	HIS69
A	CYS177

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 401

Chain	Residue
B	CYS105
B	CYS113
B	CYS99
B	CYS102

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 402

Chain	Residue
B	CYS47
B	THR49
B	HIS69
B	CYS177
B	NAD403
B	HOH506

---

site_id	AC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAD B 403

Chain	Residue
B	HIS48
B	THR49
B	PHE95
B	CYS177
B	THR181
B	GLY202
B	GLY204
B	ALA205
B	VAL206
B	ASP226
B	PHE227
B	ASN228
B	ARG231
B	CYS271
B	THR272
B	VAL295
B	VAL297
B	PHE322
B	ARG372
B	ZN402
B	HOH502

---

Functional Information from PROSITE/UniProt

site_id	PS00059
Number of Residues	15
Details	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaGGIvesvGegV

Chain	Residue	Details
A	GLY68-VAL82

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25447145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38308388","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CON","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25447145","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RQU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25447145","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38308388","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CON","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38308388","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8CON","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18433157","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19245862","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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