4RLP

Human p70s6k1 with ruthenium-based inhibitor FL772

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 72B A 401

Chain	Residue
A	LEU97
A	GLU173
A	TYR174
A	LEU175
A	GLU179
A	GLU222
A	THR235
A	GLY98
A	LYS99
A	GLY100
A	GLY103
A	VAL105
A	ALA121
A	LYS123
A	LEU172

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 403

Chain	Residue
A	ASP193

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 404

Chain	Residue
A	LYS233
A	ARG363

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 405

Chain	Residue
A	LYS325

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 406

Chain	Residue
A	GLN211
A	LYS212

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 407

Chain	Residue
A	ARG330

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGYGKVFqVrkvtgantgki.......FAMK

Chain	Residue	Details
A	LEU97-LYS123

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKpeNIML

Chain	Residue	Details
A	ILE214-LEU226

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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