Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4RJL

Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus complexed with GDPCP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 501

Chain	Residue
A	THR23
A	THR46
A	GCP527
A	HOH604
A	HOH921

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 502

Chain	Residue
A	HOH615
A	HOH920
A	VAL151
A	VAL154
A	TRP327
A	ASN328

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 503

Chain	Residue
A	THR366
A	LEU367
A	ARG383
A	ARG384

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 504

Chain	Residue
A	LEU312
A	SER364
A	THR365
A	7PG526
A	HOH658
A	HOH712

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 505

Chain	Residue
A	GLN251
A	GLU252
A	GLU344
A	MET345
A	HOH761

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 506

Chain	Residue
A	LYS64
A	TYR68
A	LEU86
A	FMT515
A	HOH937

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 507

Chain	Residue
A	PRO179
A	ILE180
A	HOH634
A	HOH802
A	HOH941
A	HOH1102

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 508

Chain	Residue
A	VAL223
A	VAL237
A	ARG280
A	HOH662
A	HOH970

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 509

Chain	Residue
A	LEU160
A	TYR163
A	ASN231
A	HOH938
A	HOH1089

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 510

Chain	Residue
A	ARG130
A	HOH770
A	HOH1007

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FMT A 511

Chain	Residue
A	ASP152
A	VAL153
A	HIS187
A	PRO324
A	LEU326
A	GCP527
A	HOH640
A	HOH696
A	HOH783
A	HOH981

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 512

Chain	Residue
A	ILE32
A	TYR51
A	GLU53
A	GLY282
A	HOH760
A	HOH880

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 513

Chain	Residue
A	ALA342
A	LYS343
A	ARG404
A	HOH699
A	HOH707
A	HOH710

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 514

Chain	Residue
A	TYR206
A	ARG207
A	ASP208
A	GLN211
A	HOH786
A	HOH789

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 515

Chain	Residue
A	GLU199
A	GLU200
A	LYS203
A	FMT506
A	HOH883
A	HOH937

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 516

Chain	Residue
A	TRP3
A	ASN55
A	PRO72
A	FMT525
A	HOH659

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 517

Chain	Residue
A	ILE32
A	LYS36
A	HOH836

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 518

Chain	Residue
A	LYS332
A	ASN334
A	TRP410
A	HOH968

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 519

Chain	Residue
A	HOH735
A	HOH850
A	HOH1043
A	LYS254
A	PRO271
A	HOH700

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 520

Chain	Residue
A	LYS212
A	GLN244
A	TRP389
A	SER390
A	HOH987

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 521

Chain	Residue
A	PRO125
A	GLU252
A	HOH656

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 522

Chain	Residue
A	LYS347
A	VAL348
A	ASP349
A	ARG399
A	ILE401

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 523

Chain	Residue
A	PRO205
A	TYR206
A	HOH998

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 524

Chain	Residue
A	PHE286
A	LYS287
A	GLU288

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 525

Chain	Residue
A	ARG88
A	FMT516
A	HOH659
A	HOH867

site_id	CC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 7PG A 526

Chain	Residue
A	ARG43
A	HIS97
A	VAL99
A	LEU100
A	ALA102
A	THR103
A	THR365
A	FMT504
A	HOH862
A	HOH932

site_id	CC9
Number of Residues	29
Details	BINDING SITE FOR RESIDUE GCP A 527

Chain	Residue
A	VAL18
A	ASP19
A	HIS20
A	GLY21
A	LYS22
A	THR23
A	THR24
A	MET45
A	THR46
A	GLY96
A	ASN149
A	LYS150
A	ASP152
A	VAL153
A	SER184
A	ALA185
A	LEU186
A	MG501
A	FMT511
A	HOH604
A	HOH606
A	HOH623
A	HOH625
A	HOH886
A	HOH921
A	HOH975
A	HOH981
A	HOH982
A	HOH983

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 528

Chain	Residue
A	THR54
A	THR70
A	HOH659
A	HOH731
A	HOH820
A	HOH1140

site_id	DC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 529

Chain	Residue
A	MET111
A	HOH627
A	HOH673
A	HOH704
A	HOH727
A	HOH732
A	HOH1048

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	199
Details	Domain: {"description":"tr-type G","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"G2","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16407071","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8U082","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)