4RJK
Acetolactate synthase from Bacillus subtilis bound to LThDP - crystal form II
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0003984 | molecular_function | acetolactate synthase activity |
A | 0030976 | molecular_function | thiamine pyrophosphate binding |
A | 0034077 | biological_process | butanediol metabolic process |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0003984 | molecular_function | acetolactate synthase activity |
B | 0030976 | molecular_function | thiamine pyrophosphate binding |
B | 0034077 | biological_process | butanediol metabolic process |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0003984 | molecular_function | acetolactate synthase activity |
C | 0030976 | molecular_function | thiamine pyrophosphate binding |
C | 0034077 | biological_process | butanediol metabolic process |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0003984 | molecular_function | acetolactate synthase activity |
D | 0030976 | molecular_function | thiamine pyrophosphate binding |
D | 0034077 | biological_process | butanediol metabolic process |
E | 0000287 | molecular_function | magnesium ion binding |
E | 0003824 | molecular_function | catalytic activity |
E | 0003984 | molecular_function | acetolactate synthase activity |
E | 0030976 | molecular_function | thiamine pyrophosphate binding |
E | 0034077 | biological_process | butanediol metabolic process |
F | 0000287 | molecular_function | magnesium ion binding |
F | 0003824 | molecular_function | catalytic activity |
F | 0003984 | molecular_function | acetolactate synthase activity |
F | 0030976 | molecular_function | thiamine pyrophosphate binding |
F | 0034077 | biological_process | butanediol metabolic process |
G | 0000287 | molecular_function | magnesium ion binding |
G | 0003824 | molecular_function | catalytic activity |
G | 0003984 | molecular_function | acetolactate synthase activity |
G | 0030976 | molecular_function | thiamine pyrophosphate binding |
G | 0034077 | biological_process | butanediol metabolic process |
H | 0000287 | molecular_function | magnesium ion binding |
H | 0003824 | molecular_function | catalytic activity |
H | 0003984 | molecular_function | acetolactate synthase activity |
H | 0030976 | molecular_function | thiamine pyrophosphate binding |
H | 0034077 | biological_process | butanediol metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE TPP A 601 |
Chain | Residue |
A | ILE398 |
A | GLY453 |
A | ASP478 |
A | THR480 |
A | TYR481 |
A | ASP482 |
A | MET483 |
A | VAL484 |
A | TYR547 |
A | MG602 |
A | HOH780 |
A | GLY399 |
A | HOH791 |
B | PRO37 |
B | GLU61 |
B | PRO87 |
B | ASN91 |
B | GLN124 |
A | SER400 |
A | HIS401 |
A | GLN424 |
A | LEU426 |
A | GLY450 |
A | ASP451 |
A | GLY452 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 602 |
Chain | Residue |
A | ASP451 |
A | ASP478 |
A | THR480 |
A | TPP601 |
A | HOH791 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 A 603 |
Chain | Residue |
A | ARG73 |
A | THR75 |
A | GLY76 |
A | ARG224 |
A | PRO225 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 A 604 |
Chain | Residue |
A | ASN386 |
A | ASP389 |
A | ASP390 |
H | ALA203 |
H | LYS207 |
H | THR210 |
H | THR304 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 A 605 |
Chain | Residue |
A | ASN100 |
A | THR101 |
A | GLN163 |
A | ASP314 |
A | PG4608 |
B | ARG121 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 A 606 |
Chain | Residue |
A | HIS391 |
A | THR393 |
A | LEU415 |
A | LYS440 |
A | GLU443 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 A 607 |
Chain | Residue |
A | ALA161 |
A | GLY162 |
A | HOH759 |
D | GLY162 |
D | PRO191 |
D | ILE312 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 A 608 |
Chain | Residue |
A | LEU97 |
A | ASN100 |
A | THR101 |
A | PRO134 |
A | PG4605 |
B | ARG121 |
B | SER125 |
site_id | AC9 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE TPP B 601 |
Chain | Residue |
A | PRO37 |
A | GLU61 |
A | PRO87 |
A | ASN91 |
A | GLN124 |
B | ILE398 |
B | GLY399 |
B | SER400 |
B | HIS401 |
B | GLN424 |
B | LEU426 |
B | GLY450 |
B | ASP451 |
B | GLY452 |
B | GLY453 |
B | ASP478 |
B | THR480 |
B | TYR481 |
B | ASP482 |
B | MET483 |
B | VAL484 |
B | TYR547 |
B | MG602 |
B | HOH812 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 602 |
Chain | Residue |
B | ASP451 |
B | ASP478 |
B | THR480 |
B | TPP601 |
B | HOH812 |
site_id | BC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 B 603 |
Chain | Residue |
B | SER160 |
B | ARG224 |
B | HOH800 |
B | GLY72 |
B | ARG73 |
B | GLY76 |
B | PRO105 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 B 604 |
Chain | Residue |
B | GLY442 |
B | PRO470 |
B | ALA535 |
B | GLU536 |
C | LYS233 |
C | GLU337 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 B 605 |
Chain | Residue |
B | SER331 |
B | ASN334 |
B | HIS335 |
C | ASP198 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 B 606 |
Chain | Residue |
B | LEU415 |
B | VAL439 |
B | LYS440 |
B | GLU443 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PG4 B 607 |
Chain | Residue |
B | ALA203 |
B | LYS207 |
B | ASP322 |
site_id | BC7 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE TPP C 601 |
Chain | Residue |
C | ILE398 |
C | GLY399 |
C | SER400 |
C | HIS401 |
C | GLN424 |
C | LEU426 |
C | GLY450 |
C | ASP451 |
C | GLY452 |
C | GLY453 |
C | PHE456 |
C | ASP478 |
C | THR480 |
C | TYR481 |
C | ASP482 |
C | MET483 |
C | VAL484 |
C | TYR547 |
C | MG602 |
C | HOH817 |
D | PRO37 |
D | GLU61 |
D | PRO87 |
D | ASN91 |
D | GLN124 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG C 602 |
Chain | Residue |
C | ASP451 |
C | ASP478 |
C | THR480 |
C | TPP601 |
C | HOH817 |
site_id | BC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PG4 C 603 |
Chain | Residue |
C | LYS207 |
C | THR304 |
site_id | CC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PG4 C 604 |
Chain | Residue |
C | LEU74 |
C | HIS391 |
C | PRO414 |
C | LEU415 |
C | THR416 |
C | VAL439 |
C | LYS440 |
C | GLU443 |
site_id | CC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PG4 C 605 |
Chain | Residue |
C | GLY72 |
C | ARG73 |
C | THR75 |
C | GLY76 |
C | PRO105 |
C | SER160 |
C | PRO225 |
C | HOH807 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 C 606 |
Chain | Residue |
B | LYS233 |
B | GLU337 |
C | LYS444 |
C | ALA535 |
C | GLU536 |
site_id | CC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PG4 C 607 |
Chain | Residue |
C | ARG121 |
D | ASN100 |
site_id | CC5 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE TPP D 601 |
Chain | Residue |
C | PRO37 |
C | GLU61 |
C | PRO87 |
C | ASN91 |
D | ILE398 |
D | GLY399 |
D | SER400 |
D | HIS401 |
D | GLN424 |
D | LEU426 |
D | GLY450 |
D | ASP451 |
D | GLY452 |
D | GLY453 |
D | ASP478 |
D | THR480 |
D | TYR481 |
D | ASP482 |
D | MET483 |
D | VAL484 |
D | TYR547 |
D | MG602 |
D | HOH707 |
site_id | CC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG D 602 |
Chain | Residue |
D | ASP451 |
D | ASP478 |
D | THR480 |
D | TPP601 |
D | HOH707 |
site_id | CC7 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PG4 D 603 |
Chain | Residue |
D | ARG254 |
D | VAL388 |
D | ASP389 |
D | ASP390 |
D | PG4609 |
E | ALA203 |
E | LYS207 |
E | THR304 |
E | ASP322 |
site_id | CC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 D 604 |
Chain | Residue |
D | GLU27 |
D | HOH760 |
E | GLY442 |
E | LYS444 |
E | PRO470 |
E | ASN534 |
E | PG4608 |
site_id | CC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PG4 D 605 |
Chain | Residue |
D | LYS207 |
D | THR210 |
D | THR304 |
H | ASN386 |
H | ALA387 |
H | ASP389 |
H | ASP390 |
H | ARG530 |
site_id | DC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 D 606 |
Chain | Residue |
D | LEU74 |
D | VAL439 |
D | LYS440 |
D | GLU443 |
site_id | DC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 D 607 |
Chain | Residue |
D | GLY72 |
D | ARG73 |
D | GLY76 |
D | SER160 |
D | ALA164 |
D | ARG224 |
D | PRO225 |
site_id | DC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 D 608 |
Chain | Residue |
D | ASP389 |
D | GLU443 |
D | LYS444 |
E | ARG186 |
E | ASP322 |
site_id | DC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 D 609 |
Chain | Residue |
D | ASP390 |
D | HIS391 |
D | GLU413 |
D | PG4603 |
E | ASP199 |
E | HOH786 |
site_id | DC5 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE TPP E 601 |
Chain | Residue |
E | ILE398 |
E | GLY399 |
E | SER400 |
E | HIS401 |
E | GLN424 |
E | LEU426 |
E | GLY450 |
E | ASP451 |
E | GLY452 |
E | GLY453 |
E | ASP478 |
E | THR480 |
E | TYR481 |
E | ASP482 |
E | MET483 |
E | VAL484 |
E | TYR547 |
E | MG602 |
E | HOH750 |
F | PRO37 |
F | GLU61 |
F | PRO87 |
F | ASN91 |
F | GLN124 |
site_id | DC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG E 602 |
Chain | Residue |
E | ASP451 |
E | ASP478 |
E | THR480 |
E | TPP601 |
E | HOH750 |
site_id | DC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 E 603 |
Chain | Residue |
A | LYS207 |
A | THR304 |
A | ASP322 |
E | ASN386 |
E | VAL388 |
E | ASP389 |
E | ASP390 |
site_id | DC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PG4 E 604 |
Chain | Residue |
D | GLY442 |
D | LYS444 |
D | PRO470 |
D | ASN534 |
D | ALA535 |
D | GLU536 |
E | GLU27 |
E | ASN184 |
site_id | DC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 E 605 |
Chain | Residue |
E | LEU74 |
E | LEU415 |
E | VAL439 |
E | LYS440 |
site_id | EC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 E 606 |
Chain | Residue |
E | ASN100 |
E | THR101 |
E | ASP288 |
E | ILE290 |
E | ASP314 |
F | ARG121 |
site_id | EC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PG4 E 607 |
Chain | Residue |
E | GLU364 |
E | LYS382 |
E | TYR408 |
site_id | EC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 E 608 |
Chain | Residue |
A | ASP322 |
D | ARG186 |
D | PG4604 |
E | ASP389 |
E | GLU443 |
E | LYS444 |
site_id | EC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 E 609 |
Chain | Residue |
E | GLY72 |
E | ARG73 |
E | GLY76 |
E | PRO105 |
E | ALA164 |
E | PRO225 |
E | HOH800 |
site_id | EC5 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE TPP F 601 |
Chain | Residue |
E | PRO37 |
E | GLU61 |
E | ASN91 |
F | GLY399 |
F | SER400 |
F | HIS401 |
F | GLN424 |
F | LEU426 |
F | GLY450 |
F | ASP451 |
F | GLY452 |
F | GLY453 |
F | ASP478 |
F | THR480 |
F | TYR481 |
F | ASP482 |
F | MET483 |
F | VAL484 |
F | TYR547 |
F | MG602 |
F | HOH753 |
F | HOH819 |
site_id | EC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG F 602 |
Chain | Residue |
F | ASP451 |
F | ASP478 |
F | THR480 |
F | TPP601 |
F | HOH819 |
site_id | EC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PG4 F 603 |
Chain | Residue |
F | ARG73 |
F | LEU74 |
F | THR75 |
F | GLY76 |
F | ARG224 |
F | PRO225 |
F | PG4606 |
F | HOH770 |
site_id | EC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 F 604 |
Chain | Residue |
F | LYS233 |
F | GLU337 |
G | ALA535 |
G | GLU536 |
site_id | EC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 F 605 |
Chain | Residue |
F | ASN534 |
F | ALA535 |
F | GLU536 |
G | LYS233 |
G | LYS237 |
G | GLU337 |
site_id | FC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 F 606 |
Chain | Residue |
F | THR393 |
F | LEU415 |
F | VAL439 |
F | LYS440 |
F | PG4603 |
site_id | FC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 F 607 |
Chain | Residue |
F | ALA161 |
F | GLY162 |
F | PRO191 |
F | LYS192 |
F | LEU193 |
F | ASP328 |
site_id | FC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PG4 F 608 |
Chain | Residue |
F | LYS207 |
F | ASP322 |
site_id | FC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PYR F 609 |
Chain | Residue |
E | GLN487 |
E | LYS491 |
F | ALA39 |
F | LYS40 |
F | GLN173 |
site_id | FC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PYR F 610 |
Chain | Residue |
F | SER437 |
F | HOH778 |
site_id | FC6 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE TPP G 601 |
Chain | Residue |
G | ILE398 |
G | GLY399 |
G | SER400 |
G | HIS401 |
G | GLN424 |
G | LEU426 |
G | GLY450 |
G | ASP451 |
G | GLY452 |
G | GLY453 |
G | ASP478 |
G | THR480 |
G | TYR481 |
G | ASP482 |
G | MET483 |
G | VAL484 |
G | TYR547 |
G | MG602 |
G | HOH738 |
H | PRO37 |
H | GLU61 |
H | PRO87 |
H | ASN91 |
site_id | FC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG G 602 |
Chain | Residue |
G | ASP451 |
G | ASP478 |
G | THR480 |
G | TPP601 |
G | HOH738 |
site_id | FC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 G 603 |
Chain | Residue |
G | ARG73 |
G | GLY76 |
G | PRO105 |
G | SER160 |
G | ARG224 |
site_id | FC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PG4 G 604 |
Chain | Residue |
G | LYS207 |
G | THR304 |
G | ASP322 |
site_id | GC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PG4 G 605 |
Chain | Residue |
G | LEU74 |
G | LEU415 |
G | LYS440 |
site_id | GC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PG4 G 606 |
Chain | Residue |
G | GLU364 |
G | TYR408 |
site_id | GC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PYR G 607 |
Chain | Residue |
F | ASP527 |
F | ASN534 |
G | GLN239 |
G | ASP258 |
G | GLN259 |
site_id | GC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PYR G 608 |
Chain | Residue |
G | GLY363 |
G | GLN365 |
G | ASP549 |
G | ASN552 |
site_id | GC5 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE TDL H 601 |
Chain | Residue |
G | PRO37 |
G | GLU61 |
G | ASN91 |
G | GLN124 |
H | ILE398 |
H | GLY399 |
H | SER400 |
H | HIS401 |
H | GLN424 |
H | LEU426 |
H | GLY450 |
H | ASP451 |
H | GLY452 |
H | GLY453 |
H | ASP478 |
H | THR480 |
H | ASP482 |
H | MET483 |
H | VAL484 |
H | TYR547 |
H | MG602 |
H | HOH760 |
site_id | GC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG H 602 |
Chain | Residue |
H | ASP451 |
H | ASP478 |
H | THR480 |
H | TDL601 |
H | HOH760 |
site_id | GC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PG4 H 603 |
Chain | Residue |
H | ASN100 |
H | PRO134 |
site_id | GC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 H 604 |
Chain | Residue |
H | GLY72 |
H | ARG73 |
H | GLY76 |
H | SER160 |
H | ALA164 |
H | ARG224 |
H | PRO225 |
site_id | GC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PYR H 605 |
Chain | Residue |
A | HIS338 |
H | LYS237 |
H | GLU337 |
Functional Information from PROSITE/UniProt
site_id | PS00187 |
Number of Residues | 20 |
Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IGaslvkPgekvVsVsGDGG |
Chain | Residue | Details |
A | ILE434-GLY453 |