4RJJ
Acetolactate synthase from Bacillus subtilis bound to ThDP - crystal form II
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0003984 | molecular_function | acetolactate synthase activity |
A | 0030976 | molecular_function | thiamine pyrophosphate binding |
A | 0034077 | biological_process | butanediol metabolic process |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0003984 | molecular_function | acetolactate synthase activity |
B | 0030976 | molecular_function | thiamine pyrophosphate binding |
B | 0034077 | biological_process | butanediol metabolic process |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0003984 | molecular_function | acetolactate synthase activity |
C | 0030976 | molecular_function | thiamine pyrophosphate binding |
C | 0034077 | biological_process | butanediol metabolic process |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0003984 | molecular_function | acetolactate synthase activity |
D | 0030976 | molecular_function | thiamine pyrophosphate binding |
D | 0034077 | biological_process | butanediol metabolic process |
E | 0000287 | molecular_function | magnesium ion binding |
E | 0003824 | molecular_function | catalytic activity |
E | 0003984 | molecular_function | acetolactate synthase activity |
E | 0030976 | molecular_function | thiamine pyrophosphate binding |
E | 0034077 | biological_process | butanediol metabolic process |
F | 0000287 | molecular_function | magnesium ion binding |
F | 0003824 | molecular_function | catalytic activity |
F | 0003984 | molecular_function | acetolactate synthase activity |
F | 0030976 | molecular_function | thiamine pyrophosphate binding |
F | 0034077 | biological_process | butanediol metabolic process |
G | 0000287 | molecular_function | magnesium ion binding |
G | 0003824 | molecular_function | catalytic activity |
G | 0003984 | molecular_function | acetolactate synthase activity |
G | 0030976 | molecular_function | thiamine pyrophosphate binding |
G | 0034077 | biological_process | butanediol metabolic process |
H | 0000287 | molecular_function | magnesium ion binding |
H | 0003824 | molecular_function | catalytic activity |
H | 0003984 | molecular_function | acetolactate synthase activity |
H | 0030976 | molecular_function | thiamine pyrophosphate binding |
H | 0034077 | biological_process | butanediol metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE TPP A 601 |
Chain | Residue |
A | ILE398 |
A | GLY453 |
A | ASP478 |
A | THR480 |
A | TYR481 |
A | ASP482 |
A | MET483 |
A | VAL484 |
A | TYR547 |
A | MG602 |
A | HOH768 |
A | GLY399 |
A | HOH861 |
B | PRO37 |
B | GLU61 |
B | PRO87 |
B | ASN91 |
B | GLN124 |
A | SER400 |
A | HIS401 |
A | GLN424 |
A | LEU426 |
A | GLY450 |
A | ASP451 |
A | GLY452 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 602 |
Chain | Residue |
A | ASP451 |
A | ASP478 |
A | THR480 |
A | TPP601 |
A | HOH861 |
site_id | AC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PG4 A 603 |
Chain | Residue |
A | GLY72 |
A | ARG73 |
A | THR75 |
A | GLY76 |
A | SER160 |
A | ALA164 |
A | ARG224 |
A | PRO225 |
A | HOH868 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 A 604 |
Chain | Residue |
A | ASN386 |
A | ASP389 |
A | ASP390 |
H | LYS207 |
H | THR304 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 A 605 |
Chain | Residue |
A | THR101 |
A | GLN163 |
A | ASP314 |
A | HOH851 |
B | ARG121 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 A 606 |
Chain | Residue |
A | LEU74 |
A | HIS391 |
A | VAL439 |
A | LYS440 |
A | GLU443 |
site_id | AC7 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE TPP B 601 |
Chain | Residue |
A | PRO37 |
A | GLU61 |
A | PRO87 |
A | ASN91 |
A | GLN124 |
B | ILE398 |
B | GLY399 |
B | SER400 |
B | HIS401 |
B | GLN424 |
B | LEU426 |
B | GLY450 |
B | ASP451 |
B | GLY452 |
B | GLY453 |
B | ASP478 |
B | THR480 |
B | TYR481 |
B | ASP482 |
B | MET483 |
B | VAL484 |
B | TYR547 |
B | MG602 |
B | HOH786 |
B | HOH907 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 602 |
Chain | Residue |
B | ASP451 |
B | ASP478 |
B | THR480 |
B | TPP601 |
B | HOH907 |
site_id | AC9 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PG4 B 603 |
Chain | Residue |
B | GLY72 |
B | ARG73 |
B | THR75 |
B | GLY76 |
B | PRO105 |
B | SER160 |
B | ARG224 |
B | PRO225 |
B | HOH917 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 B 604 |
Chain | Residue |
B | THR393 |
B | PRO414 |
B | LEU415 |
B | VAL439 |
B | LYS440 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 B 605 |
Chain | Residue |
B | LYS207 |
B | ASP322 |
B | HOH842 |
B | ALA203 |
site_id | BC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 B 606 |
Chain | Residue |
B | PRO225 |
B | GLU226 |
B | LYS229 |
B | ARG232 |
B | GLU413 |
B | PRO414 |
C | HIS391 |
site_id | BC4 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE TPP C 601 |
Chain | Residue |
C | ILE398 |
C | GLY399 |
C | SER400 |
C | HIS401 |
C | GLN424 |
C | LEU426 |
C | GLY450 |
C | ASP451 |
C | GLY452 |
C | GLY453 |
C | ASP478 |
C | THR480 |
C | TYR481 |
C | ASP482 |
C | MET483 |
C | VAL484 |
C | TYR547 |
C | MG602 |
C | HOH808 |
C | HOH931 |
D | PRO37 |
D | GLU61 |
D | PRO87 |
D | ASN91 |
D | GLN124 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG C 602 |
Chain | Residue |
C | ASP451 |
C | ASP478 |
C | THR480 |
C | TPP601 |
C | HOH931 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 C 603 |
Chain | Residue |
C | ALA203 |
C | LYS207 |
C | ASP322 |
C | HOH866 |
site_id | BC7 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PG4 C 604 |
Chain | Residue |
C | LEU74 |
C | HIS391 |
C | GLU413 |
C | PRO414 |
C | LEU415 |
C | THR416 |
C | VAL439 |
C | LYS440 |
C | HOH973 |
site_id | BC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PG4 C 605 |
Chain | Residue |
C | GLY72 |
C | ARG73 |
C | THR75 |
C | GLY76 |
C | PRO105 |
C | SER160 |
C | ARG224 |
C | PRO225 |
C | HOH878 |
C | HOH886 |
site_id | BC9 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PG4 C 606 |
Chain | Residue |
C | ALA39 |
C | GLN124 |
C | HOH783 |
C | HOH969 |
C | HOH975 |
D | LEU266 |
D | GLN424 |
D | MET483 |
D | GLN487 |
D | TPP601 |
site_id | CC1 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE TPP D 601 |
Chain | Residue |
C | PRO37 |
C | GLU61 |
C | PRO87 |
C | ASN91 |
C | GLN124 |
C | PG4606 |
D | ILE398 |
D | GLY399 |
D | SER400 |
D | HIS401 |
D | GLN424 |
D | LEU426 |
D | GLY450 |
D | ASP451 |
D | GLY452 |
D | GLY453 |
D | ASP478 |
D | THR480 |
D | TYR481 |
D | ASP482 |
D | MET483 |
D | VAL484 |
D | TYR547 |
D | MG602 |
D | HOH814 |
D | HOH898 |
site_id | CC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG D 602 |
Chain | Residue |
D | ASP451 |
D | ASP478 |
D | THR480 |
D | TPP601 |
D | HOH898 |
site_id | CC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PG4 D 603 |
Chain | Residue |
D | ARG254 |
D | ASN386 |
D | VAL388 |
D | ASP389 |
D | ASP390 |
E | ALA203 |
E | LYS207 |
E | THR304 |
E | ASP322 |
site_id | CC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 D 604 |
Chain | Residue |
D | GLU27 |
D | HOH943 |
E | GLY442 |
E | LYS444 |
E | PRO470 |
E | ASN534 |
E | HOH896 |
site_id | CC5 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PG4 D 605 |
Chain | Residue |
D | GLY442 |
D | GLU443 |
D | LYS444 |
D | PRO470 |
D | ASN534 |
D | ALA535 |
D | GLU536 |
D | HOH857 |
D | HOH901 |
E | GLU27 |
site_id | CC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PG4 D 606 |
Chain | Residue |
D | ALA206 |
D | LYS207 |
D | THR210 |
D | THR304 |
D | ASP322 |
H | ASN386 |
H | VAL388 |
H | ASP389 |
H | ASP390 |
site_id | CC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 D 607 |
Chain | Residue |
D | LEU74 |
D | VAL439 |
D | LYS440 |
D | GLU443 |
site_id | CC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ACT D 608 |
Chain | Residue |
D | ARG73 |
D | GLY76 |
site_id | CC9 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE TPP E 601 |
Chain | Residue |
E | ILE398 |
E | GLY399 |
E | SER400 |
E | HIS401 |
E | GLN424 |
E | LEU426 |
E | GLY450 |
E | ASP451 |
E | GLY452 |
E | GLY453 |
E | ASP478 |
E | THR480 |
E | TYR481 |
E | ASP482 |
E | MET483 |
E | VAL484 |
E | TYR547 |
E | MG602 |
E | PG4604 |
E | HOH792 |
E | HOH899 |
F | PRO37 |
F | GLU61 |
F | PRO87 |
F | ASN91 |
F | GLN124 |
site_id | DC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG E 602 |
Chain | Residue |
E | ASP451 |
E | ASP478 |
E | THR480 |
E | TPP601 |
E | HOH899 |
site_id | DC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PG4 E 603 |
Chain | Residue |
A | ALA203 |
A | LYS207 |
A | THR304 |
A | ASP322 |
A | LEU323 |
E | ASN386 |
E | ALA387 |
E | VAL388 |
E | ASP389 |
E | ASP390 |
site_id | DC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 E 604 |
Chain | Residue |
E | GLN424 |
E | MET483 |
E | GLN487 |
E | TPP601 |
E | HOH838 |
F | ALA39 |
F | HOH793 |
site_id | DC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 E 605 |
Chain | Residue |
E | LEU74 |
E | PRO225 |
E | VAL439 |
E | LYS440 |
E | GLU443 |
site_id | DC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PG4 E 606 |
Chain | Residue |
E | ASN100 |
E | THR101 |
E | GLN163 |
E | ASP288 |
E | ILE290 |
E | ILE311 |
E | HOH722 |
F | ARG121 |
site_id | DC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 E 607 |
Chain | Residue |
E | GLU364 |
E | LYS382 |
E | TYR408 |
E | ARG410 |
site_id | DC7 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE TPP F 601 |
Chain | Residue |
E | PRO37 |
E | GLU61 |
E | PRO87 |
E | ASN91 |
E | GLN124 |
F | ILE398 |
F | GLY399 |
F | SER400 |
F | HIS401 |
F | GLN424 |
F | LEU426 |
F | GLY450 |
F | ASP451 |
F | GLY452 |
F | GLY453 |
F | ASP478 |
F | THR480 |
F | TYR481 |
F | ASP482 |
F | MET483 |
F | VAL484 |
F | TYR547 |
F | MG602 |
F | HOH756 |
F | HOH915 |
site_id | DC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG F 602 |
Chain | Residue |
F | ASP451 |
F | ASP478 |
F | THR480 |
F | TPP601 |
F | HOH915 |
site_id | DC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 F 603 |
Chain | Residue |
F | ALA203 |
F | LYS207 |
F | THR304 |
F | ASP322 |
site_id | EC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PG4 F 604 |
Chain | Residue |
F | GLY72 |
F | ARG73 |
F | LEU74 |
F | THR75 |
F | GLY76 |
F | SER160 |
F | ALA164 |
F | ARG224 |
F | PRO225 |
F | LEU415 |
F | PG4605 |
F | HOH797 |
site_id | EC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 F 605 |
Chain | Residue |
F | LEU74 |
F | LEU415 |
F | VAL439 |
F | LYS440 |
F | PG4604 |
F | HOH952 |
site_id | EC3 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE TPP G 601 |
Chain | Residue |
G | ILE398 |
G | GLY399 |
G | SER400 |
G | HIS401 |
G | GLN424 |
G | LEU426 |
G | GLY450 |
G | ASP451 |
G | GLY452 |
G | GLY453 |
G | ASP478 |
G | THR480 |
G | TYR481 |
G | ASP482 |
G | MET483 |
G | VAL484 |
G | TYR547 |
G | MG602 |
G | HOH781 |
G | HOH890 |
H | PRO37 |
H | GLU61 |
H | PRO87 |
H | ASN91 |
H | GLN124 |
site_id | EC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG G 602 |
Chain | Residue |
G | ASP451 |
G | ASP478 |
G | THR480 |
G | TPP601 |
G | HOH890 |
site_id | EC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 G 603 |
Chain | Residue |
G | ARG73 |
G | THR75 |
G | GLY76 |
G | PRO105 |
G | SER160 |
G | ARG224 |
site_id | EC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 G 604 |
Chain | Residue |
G | ALA203 |
G | LYS207 |
G | THR304 |
G | ASP322 |
G | HOH749 |
site_id | EC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 G 605 |
Chain | Residue |
G | THR393 |
G | LEU415 |
G | VAL439 |
G | LYS440 |
G | GLU443 |
G | HOH928 |
site_id | EC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 G 606 |
Chain | Residue |
G | GLU364 |
G | LYS382 |
G | TYR408 |
G | ARG410 |
site_id | EC9 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE TPP H 601 |
Chain | Residue |
G | PRO37 |
G | GLU61 |
G | PRO87 |
G | ASN91 |
G | GLN124 |
H | ILE398 |
H | GLY399 |
H | SER400 |
H | HIS401 |
H | GLN424 |
H | LEU426 |
H | GLY450 |
H | ASP451 |
H | GLY452 |
H | GLY453 |
H | ASP478 |
H | THR480 |
H | TYR481 |
H | ASP482 |
H | MET483 |
H | VAL484 |
H | TYR547 |
H | MG602 |
H | HOH762 |
H | HOH785 |
site_id | FC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG H 602 |
Chain | Residue |
H | ASP451 |
H | ASP478 |
H | THR480 |
H | TPP601 |
H | HOH762 |
site_id | FC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PG4 H 603 |
Chain | Residue |
G | ARG121 |
G | SER125 |
H | ASN100 |
H | PRO134 |
H | ILE135 |
site_id | FC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PG4 H 604 |
Chain | Residue |
H | LEU74 |
H | LYS440 |
H | GLU443 |
H | HOH790 |
site_id | FC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 H 605 |
Chain | Residue |
H | GLY72 |
H | ARG73 |
H | THR75 |
H | GLY76 |
H | SER160 |
H | ARG224 |
Functional Information from PROSITE/UniProt
site_id | PS00187 |
Number of Residues | 20 |
Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IGaslvkPgekvVsVsGDGG |
Chain | Residue | Details |
A | ILE434-GLY453 |