4RG1
Methyltransferase domain of C9orf114
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE SAH A 401 |
| Chain | Residue |
| A | THR289 |
| A | VAL340 |
| A | ASN341 |
| A | THR342 |
| A | GLN346 |
| A | THR350 |
| A | ILE351 |
| A | THR353 |
| A | ALA356 |
| A | HOH516 |
| A | HOH534 |
| A | SER290 |
| A | HOH545 |
| A | HOH585 |
| A | HOH682 |
| A | HOH706 |
| A | HOH742 |
| A | GLU291 |
| A | ARG292 |
| A | PHE311 |
| A | GLY312 |
| A | GLY313 |
| A | LEU314 |
| A | GLY316 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 15P A 402 |
| Chain | Residue |
| A | GLN147 |
| A | GLU150 |
| A | TYR262 |
| A | THR263 |
| A | VAL264 |
| A | 15P403 |
| A | HOH505 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 15P A 403 |
| Chain | Residue |
| A | ASP110 |
| A | GLU191 |
| A | SER249 |
| A | GLN250 |
| A | TRP260 |
| A | GLY261 |
| A | THR263 |
| A | 15P402 |
| A | HOH663 |
| A | HOH723 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAH B 401 |
| Chain | Residue |
| B | THR289 |
| B | SER290 |
| B | GLU291 |
| B | ARG292 |
| B | PHE311 |
| B | GLY312 |
| B | GLY313 |
| B | LEU314 |
| B | GLY316 |
| B | VAL340 |
| B | ASN341 |
| B | THR342 |
| B | GLN346 |
| B | ILE351 |
| B | THR353 |
| B | ALA356 |
| B | HOH577 |
| B | HOH578 |
| B | HOH587 |
| B | HOH645 |
| B | HOH791 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGO B 402 |
| Chain | Residue |
| B | TYR95 |
| B | GLY98 |
| B | GLN99 |
| B | ARG102 |
| B | LEU172 |
| B | ASN173 |
| B | HOH817 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 15P B 403 |
| Chain | Residue |
| B | ASP110 |
| B | SER249 |
| B | GLN250 |
| B | TRP260 |
| B | THR263 |
| B | 15P404 |
| B | HOH768 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 15P B 404 |
| Chain | Residue |
| B | VAL140 |
| B | GLN147 |
| B | GLU150 |
| B | ARG226 |
| B | THR263 |
| B | VAL264 |
| B | 15P403 |
| B | HOH525 |
| B | HOH767 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2014","submissionDatabase":"PDB data bank","title":"The Crystal Structure of Human C9orf114 in complex with S-adenosyl-homocysteine.","authors":["Zeng H.","Dong A.","Walker J.R.","Li Y.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Brown P.J.","Wu H."]}},{"source":"PDB","id":"4RG1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QSU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"8QSV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
