4RFQ

Human Methyltransferase-Like 18

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE SAM A 401

Chain	Residue
A	PRO78
A	GLN216
A	ASP217
A	TYR218
A	GLY268
A	GLU269
A	TRP270
A	SER293
A	THR295
A	TYR301
A	HOH507
A	GLU89
A	HOH509
A	HOH510
A	HOH521
A	PRO90
A	ILE168
A	TRP169
A	THR172
A	GLY195
A	CYS196
A	GLY197

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2014","submissionDatabase":"PDB data bank","title":"Human Methyltransferase-Like 18.","authors":["Ravichandran M.","Tempel W.","Li Y.","Walker J.R.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Brown P.J.","Hong B.S."]}},{"source":"PDB","id":"4RFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2014","submissionDatabase":"PDB data bank","title":"Human Methyltransferase-Like 18.","authors":["Ravichandran M.","Tempel W.","Li Y.","Walker J.R.","Bountra C.","Arrowsmith C.H.","Edwards A.M.","Brown P.J.","Hong B.S."]}},{"source":"PubMed","id":"35674491","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4RFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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