4RE9
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001618 | molecular_function | virus receptor activity |
A | 0004175 | molecular_function | endopeptidase activity |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005777 | cellular_component | peroxisome |
A | 0005782 | cellular_component | peroxisomal matrix |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0008286 | biological_process | insulin receptor signaling pathway |
A | 0009897 | cellular_component | external side of plasma membrane |
A | 0009986 | cellular_component | cell surface |
A | 0010815 | biological_process | bradykinin catabolic process |
A | 0010992 | biological_process | ubiquitin recycling |
A | 0016323 | cellular_component | basolateral plasma membrane |
A | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
A | 0030163 | biological_process | protein catabolic process |
A | 0032092 | biological_process | positive regulation of protein binding |
A | 0042277 | molecular_function | peptide binding |
A | 0042447 | biological_process | hormone catabolic process |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0043171 | biological_process | peptide catabolic process |
A | 0043559 | molecular_function | insulin binding |
A | 0045732 | biological_process | positive regulation of protein catabolic process |
A | 0046718 | biological_process | symbiont entry into host cell |
A | 0046872 | molecular_function | metal ion binding |
A | 0050435 | biological_process | amyloid-beta metabolic process |
A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
A | 0070062 | cellular_component | extracellular exosome |
A | 0097242 | biological_process | amyloid-beta clearance |
A | 0150094 | biological_process | amyloid-beta clearance by cellular catabolic process |
A | 1901142 | biological_process | insulin metabolic process |
A | 1901143 | biological_process | insulin catabolic process |
A | 1903715 | biological_process | regulation of aerobic respiration |
B | 0001618 | molecular_function | virus receptor activity |
B | 0004175 | molecular_function | endopeptidase activity |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005777 | cellular_component | peroxisome |
B | 0005782 | cellular_component | peroxisomal matrix |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0008286 | biological_process | insulin receptor signaling pathway |
B | 0009897 | cellular_component | external side of plasma membrane |
B | 0009986 | cellular_component | cell surface |
B | 0010815 | biological_process | bradykinin catabolic process |
B | 0010992 | biological_process | ubiquitin recycling |
B | 0016323 | cellular_component | basolateral plasma membrane |
B | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
B | 0030163 | biological_process | protein catabolic process |
B | 0032092 | biological_process | positive regulation of protein binding |
B | 0042277 | molecular_function | peptide binding |
B | 0042447 | biological_process | hormone catabolic process |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0043171 | biological_process | peptide catabolic process |
B | 0043559 | molecular_function | insulin binding |
B | 0045732 | biological_process | positive regulation of protein catabolic process |
B | 0046718 | biological_process | symbiont entry into host cell |
B | 0046872 | molecular_function | metal ion binding |
B | 0050435 | biological_process | amyloid-beta metabolic process |
B | 0051603 | biological_process | proteolysis involved in protein catabolic process |
B | 0070062 | cellular_component | extracellular exosome |
B | 0097242 | biological_process | amyloid-beta clearance |
B | 0150094 | biological_process | amyloid-beta clearance by cellular catabolic process |
B | 1901142 | biological_process | insulin metabolic process |
B | 1901143 | biological_process | insulin catabolic process |
B | 1903715 | biological_process | regulation of aerobic respiration |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1101 |
Chain | Residue |
A | HIS108 |
A | HIS112 |
A | GLU189 |
A | 3M91102 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 3M9 A 1102 |
Chain | Residue |
A | ASN139 |
A | ALA140 |
A | GLU189 |
A | ARG824 |
A | TYR831 |
A | ZN1101 |
A | PEG1104 |
A | HIS108 |
A | GLU111 |
A | HIS112 |
A | PHE115 |
A | SER128 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EPE A 1103 |
Chain | Residue |
A | GLN800 |
A | ARG839 |
A | ALA840 |
A | ASN841 |
A | GLY842 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PEG A 1104 |
Chain | Residue |
A | HIS679 |
A | 3M91102 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PEG A 1105 |
Chain | Residue |
A | SER590 |
A | ASN622 |
A | TYR666 |
site_id | AC6 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE PEG A 1106 |
Chain | Residue |
A | ARG477 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PEG A 1107 |
Chain | Residue |
A | ALA198 |
A | TRP199 |
A | PHE202 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PEG A 1108 |
Chain | Residue |
A | VAL360 |
A | GLY361 |
A | GLN363 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PEG A 1109 |
Chain | Residue |
A | THR358 |
A | VAL360 |
A | ASN376 |
site_id | BC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE 1PE A 1110 |
Chain | Residue |
A | GLN323 |
A | TYR326 |
A | ASN329 |
A | HIS332 |
A | ASN418 |
A | TYR444 |
A | ALA452 |
A | GLU453 |
A | TYR454 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 1101 |
Chain | Residue |
B | HIS108 |
B | HIS112 |
B | GLU189 |
B | 3M91102 |
site_id | BC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE 3M9 B 1102 |
Chain | Residue |
B | HIS108 |
B | GLU111 |
B | HIS112 |
B | SER128 |
B | ASN139 |
B | ALA140 |
B | GLU189 |
B | ARG824 |
B | TYR831 |
B | ZN1101 |
site_id | BC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EPE B 1103 |
Chain | Residue |
B | GLN800 |
B | ARG839 |
B | ALA840 |
B | ASN841 |
B | GLY842 |
B | SER913 |
B | ARG920 |
B | HOH1207 |
site_id | BC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE PEG B 1104 |
Chain | Residue |
B | PEG1105 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PEG B 1105 |
Chain | Residue |
B | GLY339 |
B | GLU341 |
B | LEU359 |
B | VAL360 |
B | GLY361 |
B | PEG1104 |
site_id | BC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PEG B 1106 |
Chain | Residue |
B | MET683 |
B | ARG847 |
site_id | BC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PEG B 1107 |
Chain | Residue |
B | ALA198 |
B | TRP199 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE 1PE B 1108 |
Chain | Residue |
B | SER590 |
B | ASN622 |
B | SER669 |
B | LYS697 |
site_id | CC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EDO B 1109 |
Chain | Residue |
B | GLN621 |
Functional Information from PROSITE/UniProt
site_id | PS00143 |
Number of Residues | 24 |
Details | INSULINASE Insulinase family, zinc-binding region signature. GslsdppniaGlSHFLEHMlFlGT |
Chain | Residue | Details |
A | GLY95-THR118 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390 |
Chain | Residue | Details |
A | GLU111 | |
B | GLU111 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57 |
Chain | Residue | Details |
A | HIS108 | |
A | HIS112 | |
A | GLU189 | |
B | HIS108 | |
B | HIS112 | |
B | GLU189 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: in the exosite |
Chain | Residue | Details |
A | HIS336 | |
B | HIS336 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18986166 |
Chain | Residue | Details |
A | LEU359 | |
B | LEU359 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P35559 |
Chain | Residue | Details |
A | ARG429 | |
A | ASP895 | |
B | ARG429 | |
B | ASP895 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7 |
Chain | Residue | Details |
A | LYS192 | |
A | LYS697 | |
B | LYS192 | |
B | LYS697 |