4RDH
Crystal structure of E. coli tRNA N6-threonylcarbamoyladenosine dehydratase, TcdA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016874 | molecular_function | ligase activity |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0031402 | molecular_function | sodium ion binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0061503 | molecular_function | tRNA threonylcarbamoyladenosine dehydratase |
| A | 0061504 | biological_process | cyclic threonylcarbamoyladenosine biosynthetic process |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016874 | molecular_function | ligase activity |
| B | 0030955 | molecular_function | potassium ion binding |
| B | 0031402 | molecular_function | sodium ion binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0061503 | molecular_function | tRNA threonylcarbamoyladenosine dehydratase |
| B | 0061504 | biological_process | cyclic threonylcarbamoyladenosine biosynthetic process |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| C | 0016020 | cellular_component | membrane |
| C | 0016874 | molecular_function | ligase activity |
| C | 0030955 | molecular_function | potassium ion binding |
| C | 0031402 | molecular_function | sodium ion binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0061503 | molecular_function | tRNA threonylcarbamoyladenosine dehydratase |
| C | 0061504 | biological_process | cyclic threonylcarbamoyladenosine biosynthetic process |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| D | 0016020 | cellular_component | membrane |
| D | 0016874 | molecular_function | ligase activity |
| D | 0030955 | molecular_function | potassium ion binding |
| D | 0031402 | molecular_function | sodium ion binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0061503 | molecular_function | tRNA threonylcarbamoyladenosine dehydratase |
| D | 0061504 | biological_process | cyclic threonylcarbamoyladenosine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE AMP A 301 |
| Chain | Residue |
| A | VAL36 |
| A | LYS85 |
| A | PHE108 |
| A | VAL109 |
| A | ILE129 |
| A | ASP130 |
| A | SER131 |
| A | PRO134 |
| A | HOH460 |
| A | HOH462 |
| A | HOH467 |
| A | GLY37 |
| A | HOH493 |
| A | GLY39 |
| A | GLY40 |
| A | ILE60 |
| A | ASP61 |
| A | ASP63 |
| A | ARG72 |
| A | GLN73 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 302 |
| Chain | Residue |
| A | CYS142 |
| A | ILE147 |
| A | PRO148 |
| A | LEU149 |
| A | GLY200 |
| A | VAL201 |
| A | ASP202 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE AMP B 301 |
| Chain | Residue |
| B | GLY37 |
| B | GLY39 |
| B | GLY40 |
| B | ILE60 |
| B | ASP61 |
| B | ASP63 |
| B | ARG72 |
| B | GLN73 |
| B | LYS85 |
| B | PHE108 |
| B | VAL109 |
| B | ILE129 |
| B | ASP130 |
| B | SER131 |
| B | PRO134 |
| B | HOH414 |
| B | HOH427 |
| B | HOH454 |
| B | HOH495 |
| B | HOH504 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 302 |
| Chain | Residue |
| B | ILE147 |
| B | PRO148 |
| B | LEU149 |
| B | GLY200 |
| B | VAL201 |
| B | ASP202 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE AMP C 301 |
| Chain | Residue |
| C | GLY37 |
| C | GLY39 |
| C | GLY40 |
| C | ASP61 |
| C | ASP63 |
| C | ARG72 |
| C | GLN73 |
| C | LYS85 |
| C | PHE108 |
| C | VAL109 |
| C | ILE129 |
| C | ASP130 |
| C | SER131 |
| C | PRO134 |
| C | HOH410 |
| C | HOH441 |
| C | HOH493 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 302 |
| Chain | Residue |
| C | CYS142 |
| C | ILE147 |
| C | PRO148 |
| C | LEU149 |
| C | GLY200 |
| C | VAL201 |
| C | ASP202 |
| C | HOH474 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 303 |
| Chain | Residue |
| A | LYS171 |
| C | THR68 |
| C | ASN69 |
| C | ARG72 |
| C | HOH410 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE AMP D 301 |
| Chain | Residue |
| D | HOH470 |
| D | HOH471 |
| D | GLY37 |
| D | GLY39 |
| D | GLY40 |
| D | ILE60 |
| D | ASP61 |
| D | ASP63 |
| D | ARG72 |
| D | GLN73 |
| D | LYS85 |
| D | PHE108 |
| D | VAL109 |
| D | ILE129 |
| D | ASP130 |
| D | PRO134 |
| D | HOH408 |
| D | HOH426 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 302 |
| Chain | Residue |
| D | CYS142 |
| D | ILE147 |
| D | PRO148 |
| D | LEU149 |
| D | GLY200 |
| D | VAL201 |
| D | ASP202 |
| D | HOH434 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY237-LEU257 | |
| B | GLY237-LEU257 | |
| C | GLY237-LEU257 | |
| D | GLY237-LEU257 |
