4RAU

crystal structure of RTOFab in complex with human PF4

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0002548	biological_process	monocyte chemotaxis
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0006935	biological_process	chemotaxis
C	0006952	biological_process	defense response
C	0006954	biological_process	inflammatory response
C	0006955	biological_process	immune response
C	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
C	0008009	molecular_function	chemokine activity
C	0008201	molecular_function	heparin binding
C	0010628	biological_process	positive regulation of gene expression
C	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
C	0016525	biological_process	negative regulation of angiogenesis
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0030168	biological_process	platelet activation
C	0030593	biological_process	neutrophil chemotaxis
C	0030595	biological_process	leukocyte chemotaxis
C	0031093	cellular_component	platelet alpha granule lumen
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0042127	biological_process	regulation of cell population proliferation
C	0042832	biological_process	defense response to protozoan
C	0045236	molecular_function	CXCR chemokine receptor binding
C	0045347	biological_process	negative regulation of MHC class II biosynthetic process
C	0045651	biological_process	positive regulation of macrophage differentiation
C	0045653	biological_process	negative regulation of megakaryocyte differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0048248	molecular_function	CXCR3 chemokine receptor binding
C	0051873	biological_process	killing by host of symbiont cells
C	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
C	0062023	cellular_component	collagen-containing extracellular matrix
C	0070098	biological_process	chemokine-mediated signaling pathway
C	0071222	biological_process	cellular response to lipopolysaccharide
C	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
F	0002548	biological_process	monocyte chemotaxis
F	0005125	molecular_function	cytokine activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0006935	biological_process	chemotaxis
F	0006952	biological_process	defense response
F	0006954	biological_process	inflammatory response
F	0006955	biological_process	immune response
F	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
F	0008009	molecular_function	chemokine activity
F	0008201	molecular_function	heparin binding
F	0010628	biological_process	positive regulation of gene expression
F	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
F	0016525	biological_process	negative regulation of angiogenesis
F	0019221	biological_process	cytokine-mediated signaling pathway
F	0030168	biological_process	platelet activation
F	0030593	biological_process	neutrophil chemotaxis
F	0030595	biological_process	leukocyte chemotaxis
F	0031093	cellular_component	platelet alpha granule lumen
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0042127	biological_process	regulation of cell population proliferation
F	0042832	biological_process	defense response to protozoan
F	0045236	molecular_function	CXCR chemokine receptor binding
F	0045347	biological_process	negative regulation of MHC class II biosynthetic process
F	0045651	biological_process	positive regulation of macrophage differentiation
F	0045653	biological_process	negative regulation of megakaryocyte differentiation
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0048248	molecular_function	CXCR3 chemokine receptor binding
F	0051873	biological_process	killing by host of symbiont cells
F	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
F	0062023	cellular_component	collagen-containing extracellular matrix
F	0070098	biological_process	chemokine-mediated signaling pathway
F	0071222	biological_process	cellular response to lipopolysaccharide
F	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
I	0002548	biological_process	monocyte chemotaxis
I	0005125	molecular_function	cytokine activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005737	cellular_component	cytoplasm
I	0006935	biological_process	chemotaxis
I	0006952	biological_process	defense response
I	0006954	biological_process	inflammatory response
I	0006955	biological_process	immune response
I	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
I	0008009	molecular_function	chemokine activity
I	0008201	molecular_function	heparin binding
I	0010628	biological_process	positive regulation of gene expression
I	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
I	0016525	biological_process	negative regulation of angiogenesis
I	0019221	biological_process	cytokine-mediated signaling pathway
I	0030168	biological_process	platelet activation
I	0030593	biological_process	neutrophil chemotaxis
I	0030595	biological_process	leukocyte chemotaxis
I	0031093	cellular_component	platelet alpha granule lumen
I	0032760	biological_process	positive regulation of tumor necrosis factor production
I	0042127	biological_process	regulation of cell population proliferation
I	0042832	biological_process	defense response to protozoan
I	0045236	molecular_function	CXCR chemokine receptor binding
I	0045347	biological_process	negative regulation of MHC class II biosynthetic process
I	0045651	biological_process	positive regulation of macrophage differentiation
I	0045653	biological_process	negative regulation of megakaryocyte differentiation
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0048248	molecular_function	CXCR3 chemokine receptor binding
I	0051873	biological_process	killing by host of symbiont cells
I	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
I	0062023	cellular_component	collagen-containing extracellular matrix
I	0070098	biological_process	chemokine-mediated signaling pathway
I	0071222	biological_process	cellular response to lipopolysaccharide
I	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
L	0002548	biological_process	monocyte chemotaxis
L	0005125	molecular_function	cytokine activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005737	cellular_component	cytoplasm
L	0006935	biological_process	chemotaxis
L	0006952	biological_process	defense response
L	0006954	biological_process	inflammatory response
L	0006955	biological_process	immune response
L	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
L	0008009	molecular_function	chemokine activity
L	0008201	molecular_function	heparin binding
L	0010628	biological_process	positive regulation of gene expression
L	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
L	0016525	biological_process	negative regulation of angiogenesis
L	0019221	biological_process	cytokine-mediated signaling pathway
L	0030168	biological_process	platelet activation
L	0030593	biological_process	neutrophil chemotaxis
L	0030595	biological_process	leukocyte chemotaxis
L	0031093	cellular_component	platelet alpha granule lumen
L	0032760	biological_process	positive regulation of tumor necrosis factor production
L	0042127	biological_process	regulation of cell population proliferation
L	0042832	biological_process	defense response to protozoan
L	0045236	molecular_function	CXCR chemokine receptor binding
L	0045347	biological_process	negative regulation of MHC class II biosynthetic process
L	0045651	biological_process	positive regulation of macrophage differentiation
L	0045653	biological_process	negative regulation of megakaryocyte differentiation
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0048248	molecular_function	CXCR3 chemokine receptor binding
L	0051873	biological_process	killing by host of symbiont cells
L	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
L	0062023	cellular_component	collagen-containing extracellular matrix
L	0070098	biological_process	chemokine-mediated signaling pathway
L	0071222	biological_process	cellular response to lipopolysaccharide
L	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
O	0002548	biological_process	monocyte chemotaxis
O	0005125	molecular_function	cytokine activity
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005615	cellular_component	extracellular space
O	0005737	cellular_component	cytoplasm
O	0006935	biological_process	chemotaxis
O	0006952	biological_process	defense response
O	0006954	biological_process	inflammatory response
O	0006955	biological_process	immune response
O	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
O	0008009	molecular_function	chemokine activity
O	0008201	molecular_function	heparin binding
O	0010628	biological_process	positive regulation of gene expression
O	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
O	0016525	biological_process	negative regulation of angiogenesis
O	0019221	biological_process	cytokine-mediated signaling pathway
O	0030168	biological_process	platelet activation
O	0030593	biological_process	neutrophil chemotaxis
O	0030595	biological_process	leukocyte chemotaxis
O	0031093	cellular_component	platelet alpha granule lumen
O	0032760	biological_process	positive regulation of tumor necrosis factor production
O	0042127	biological_process	regulation of cell population proliferation
O	0042832	biological_process	defense response to protozoan
O	0045236	molecular_function	CXCR chemokine receptor binding
O	0045347	biological_process	negative regulation of MHC class II biosynthetic process
O	0045651	biological_process	positive regulation of macrophage differentiation
O	0045653	biological_process	negative regulation of megakaryocyte differentiation
O	0045944	biological_process	positive regulation of transcription by RNA polymerase II
O	0048248	molecular_function	CXCR3 chemokine receptor binding
O	0051873	biological_process	killing by host of symbiont cells
O	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
O	0062023	cellular_component	collagen-containing extracellular matrix
O	0070098	biological_process	chemokine-mediated signaling pathway
O	0071222	biological_process	cellular response to lipopolysaccharide
O	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
R	0002548	biological_process	monocyte chemotaxis
R	0005125	molecular_function	cytokine activity
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005615	cellular_component	extracellular space
R	0005737	cellular_component	cytoplasm
R	0006935	biological_process	chemotaxis
R	0006952	biological_process	defense response
R	0006954	biological_process	inflammatory response
R	0006955	biological_process	immune response
R	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
R	0008009	molecular_function	chemokine activity
R	0008201	molecular_function	heparin binding
R	0010628	biological_process	positive regulation of gene expression
R	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
R	0016525	biological_process	negative regulation of angiogenesis
R	0019221	biological_process	cytokine-mediated signaling pathway
R	0030168	biological_process	platelet activation
R	0030593	biological_process	neutrophil chemotaxis
R	0030595	biological_process	leukocyte chemotaxis
R	0031093	cellular_component	platelet alpha granule lumen
R	0032760	biological_process	positive regulation of tumor necrosis factor production
R	0042127	biological_process	regulation of cell population proliferation
R	0042832	biological_process	defense response to protozoan
R	0045236	molecular_function	CXCR chemokine receptor binding
R	0045347	biological_process	negative regulation of MHC class II biosynthetic process
R	0045651	biological_process	positive regulation of macrophage differentiation
R	0045653	biological_process	negative regulation of megakaryocyte differentiation
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0048248	molecular_function	CXCR3 chemokine receptor binding
R	0051873	biological_process	killing by host of symbiont cells
R	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
R	0062023	cellular_component	collagen-containing extracellular matrix
R	0070098	biological_process	chemokine-mediated signaling pathway
R	0071222	biological_process	cellular response to lipopolysaccharide
R	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
U	0002548	biological_process	monocyte chemotaxis
U	0005125	molecular_function	cytokine activity
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005615	cellular_component	extracellular space
U	0005737	cellular_component	cytoplasm
U	0006935	biological_process	chemotaxis
U	0006952	biological_process	defense response
U	0006954	biological_process	inflammatory response
U	0006955	biological_process	immune response
U	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
U	0008009	molecular_function	chemokine activity
U	0008201	molecular_function	heparin binding
U	0010628	biological_process	positive regulation of gene expression
U	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
U	0016525	biological_process	negative regulation of angiogenesis
U	0019221	biological_process	cytokine-mediated signaling pathway
U	0030168	biological_process	platelet activation
U	0030593	biological_process	neutrophil chemotaxis
U	0030595	biological_process	leukocyte chemotaxis
U	0031093	cellular_component	platelet alpha granule lumen
U	0032760	biological_process	positive regulation of tumor necrosis factor production
U	0042127	biological_process	regulation of cell population proliferation
U	0042832	biological_process	defense response to protozoan
U	0045236	molecular_function	CXCR chemokine receptor binding
U	0045347	biological_process	negative regulation of MHC class II biosynthetic process
U	0045651	biological_process	positive regulation of macrophage differentiation
U	0045653	biological_process	negative regulation of megakaryocyte differentiation
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0048248	molecular_function	CXCR3 chemokine receptor binding
U	0051873	biological_process	killing by host of symbiont cells
U	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
U	0062023	cellular_component	collagen-containing extracellular matrix
U	0070098	biological_process	chemokine-mediated signaling pathway
U	0071222	biological_process	cellular response to lipopolysaccharide
U	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
X	0002548	biological_process	monocyte chemotaxis
X	0005125	molecular_function	cytokine activity
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005615	cellular_component	extracellular space
X	0005737	cellular_component	cytoplasm
X	0006935	biological_process	chemotaxis
X	0006952	biological_process	defense response
X	0006954	biological_process	inflammatory response
X	0006955	biological_process	immune response
X	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
X	0008009	molecular_function	chemokine activity
X	0008201	molecular_function	heparin binding
X	0010628	biological_process	positive regulation of gene expression
X	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
X	0016525	biological_process	negative regulation of angiogenesis
X	0019221	biological_process	cytokine-mediated signaling pathway
X	0030168	biological_process	platelet activation
X	0030593	biological_process	neutrophil chemotaxis
X	0030595	biological_process	leukocyte chemotaxis
X	0031093	cellular_component	platelet alpha granule lumen
X	0032760	biological_process	positive regulation of tumor necrosis factor production
X	0042127	biological_process	regulation of cell population proliferation
X	0042832	biological_process	defense response to protozoan
X	0045236	molecular_function	CXCR chemokine receptor binding
X	0045347	biological_process	negative regulation of MHC class II biosynthetic process
X	0045651	biological_process	positive regulation of macrophage differentiation
X	0045653	biological_process	negative regulation of megakaryocyte differentiation
X	0045944	biological_process	positive regulation of transcription by RNA polymerase II
X	0048248	molecular_function	CXCR3 chemokine receptor binding
X	0051873	biological_process	killing by host of symbiont cells
X	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
X	0062023	cellular_component	collagen-containing extracellular matrix
X	0070098	biological_process	chemokine-mediated signaling pathway
X	0071222	biological_process	cellular response to lipopolysaccharide
X	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
A	TYR194-HIS200

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site_id	PS00471
Number of Residues	45
Details	SMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. ClCVkttsq.VrpRhItsLevikaGphCptaQLIatlkngrki.CLD

Chain	Residue	Details
C	CYS10-ASP54

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
C	LYS61
F	LYS61
I	LYS61
L	LYS61
O	LYS61
R	LYS61
U	LYS61
X	LYS61

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site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06765

Chain	Residue	Details
C	SER26
F	SER26
I	SER26
L	SER26
O	SER26
R	SER26
U	SER26
X	SER26

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