4R9M

Crystal structure of spermidine N-acetyltransferase from Escherichia coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004145	molecular_function	diamine N-acetyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006598	biological_process	polyamine catabolic process
A	0015936	biological_process	coenzyme A metabolic process
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0046203	biological_process	spermidine catabolic process
A	0046208	biological_process	spermine catabolic process
A	0046872	molecular_function	metal ion binding
A	1990235	cellular_component	diamine N-acetyltransferase complex
B	0000287	molecular_function	magnesium ion binding
B	0004145	molecular_function	diamine N-acetyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006598	biological_process	polyamine catabolic process
B	0015936	biological_process	coenzyme A metabolic process
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0046203	biological_process	spermidine catabolic process
B	0046208	biological_process	spermine catabolic process
B	0046872	molecular_function	metal ion binding
B	1990235	cellular_component	diamine N-acetyltransferase complex
C	0000287	molecular_function	magnesium ion binding
C	0004145	molecular_function	diamine N-acetyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006598	biological_process	polyamine catabolic process
C	0015936	biological_process	coenzyme A metabolic process
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0046203	biological_process	spermidine catabolic process
C	0046208	biological_process	spermine catabolic process
C	0046872	molecular_function	metal ion binding
C	1990235	cellular_component	diamine N-acetyltransferase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 201

Chain	Residue
A	GLU35
A	GLU35
A	GLU76
A	GLU76

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:33826189

Chain	Residue	Details
A	TYR135
B	TYR135
C	TYR135

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site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9KL03

Chain	Residue	Details
A	GLN95
A	ASN128
B	MET30
B	GLU35
B	GLU43
B	HIS51
B	GLU85
B	ILE88
B	GLN95
B	ASN128
C	MET30
C	GLU35
C	GLU43
C	HIS51
C	GLU85
C	ILE88
C	GLN95
C	ASN128
A	MET30
A	GLU35
A	GLU43
A	HIS51
A	GLU85
A	ILE88

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:31205017, ECO:0007744|PDB:4R9M

Chain	Residue	Details
A	GLU76
B	GLU76
C	GLU76

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site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Could be important for selectivity toward long polyamines => ECO:0000250|UniProtKB:Q9KL03

Chain	Residue	Details
A	GLU85
B	GLU85
C	GLU85

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