4R8K

Crystal structure of the guinea pig L-asparaginase 1 catalytic domain

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EPE A 700

Chain	Residue
A	GLY18
D	ASN272
A	THR19
A	ASP84
A	SER85
A	GLY115
A	THR116
A	ASP117
A	HOH819
A	HOH832

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EPE B 700

Chain	Residue
B	GLY18
B	THR19
B	ASP84
B	SER85
B	GLY115
B	THR116
B	ASP117
C	ASN272

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site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EPE C 700

Chain	Residue
B	ASN272
B	HOH802
C	GLY18
C	THR19
C	ASP84
C	SER85
C	GLY115
C	THR116
C	ASP117
C	HOH864

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site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE EPE D 700

Chain	Residue
A	ASN272
D	GLY18
D	THR19
D	LEU29
D	ASP84
D	SER85
D	GLY115
D	THR116
D	ASP117
D	HOH847
D	HOH859
D	HOH902

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site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EPE E 700

Chain	Residue
E	GLY18
E	THR19
E	ASP84
E	SER85
E	GLY115
E	THR116
E	ASP117
H	ASN272

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site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE EPE F 700

Chain	Residue
F	GLY18
F	THR19
F	LEU29
F	ASP84
F	SER85
F	GLY115
F	THR116
F	ASP117
F	HOH820
F	HOH824
G	ASN272

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site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE EPE G 700

Chain	Residue
F	ASN272
G	GLY18
G	THR19
G	LEU29
G	ASP84
G	SER85
G	GLY115
G	THR116
G	ASP117
G	HOH864
G	HOH908

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site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE EPE H 700

Chain	Residue
E	ASN272
H	GLY18
H	THR19
H	ASP84
H	SER85
H	GLY115
H	THR116
H	ASP117
H	HOH804
H	HOH809
H	HOH849

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Functional Information from PROSITE/UniProt

site_id	PS00917
Number of Residues	11
Details	ASN_GLN_ASE_2 Asparaginase / glutaminase active site signature 2. GfVviHGTDTM

Chain	Residue	Details
A	GLY109-MET119

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