4R7Y

Crystal structure of an active MCM hexamer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005524	molecular_function	ATP binding
B	0003677	molecular_function	DNA binding
B	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP A 2001

Chain	Residue
A	ALA1289
A	GLN1336
A	ASN1803
A	ILE1851
A	MG2002
B	ALA1922
A	ILE1290
A	TYR1291
A	PRO1330
A	GLY1331
A	VAL1332
A	ALA1333
A	LYS1334
A	SER1335

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 2002

Chain	Residue
A	SER1335
A	ADP2001

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2003

Chain	Residue
A	HIS144
A	CYS149
A	CYS171
A	CYS174

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 2004

Chain	Residue
A	VAL106

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 2005

Chain	Residue
A	ARG230
A	ASN1793

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 2006

Chain	Residue
A	ARG105
A	LYS119

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP B 2001

Chain	Residue
B	ALA1289
B	ILE1290
B	TYR1291
B	TYR1293
B	ASP1329
B	PRO1330
B	GLY1331
B	VAL1332
B	ALA1333
B	LYS1334
B	SER1335
B	ASN1803
B	ILE1851
B	MG2002

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 2002

Chain	Residue
B	SER1335
B	ADP2001

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2003

Chain	Residue
B	HIS144
B	CYS149
B	CYS171
B	CYS174

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 2004

Chain	Residue
B	VAL106

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 2005

Chain	Residue
B	ARG230
B	ASN1793

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 2006

Chain	Residue
B	ARG105
B	LYS119

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18417534","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36499022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VL6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FDG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"36499022","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31308367","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31308367","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36499022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	14
Details	Motif: {"description":"Walker A","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Motif: {"description":"Walker B","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31308367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Site: {"description":"Arginine finger","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17964268","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---