Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4R53

dihydrodipicolinate synthase from C. jejuni with vacant active site and vacant allosteric site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
A	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
A	0009085	biological_process	lysine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0009436	biological_process	glyoxylate catabolic process
A	0016829	molecular_function	lyase activity
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0044281	biological_process	small molecule metabolic process
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008652	biological_process	amino acid biosynthetic process
B	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
B	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
B	0009085	biological_process	lysine biosynthetic process
B	0009089	biological_process	lysine biosynthetic process via diaminopimelate
B	0009436	biological_process	glyoxylate catabolic process
B	0016829	molecular_function	lyase activity
B	0019877	biological_process	diaminopimelate biosynthetic process
B	0044281	biological_process	small molecule metabolic process
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
C	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
C	0009085	biological_process	lysine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0009436	biological_process	glyoxylate catabolic process
C	0016829	molecular_function	lyase activity
C	0019877	biological_process	diaminopimelate biosynthetic process
C	0044281	biological_process	small molecule metabolic process
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008652	biological_process	amino acid biosynthetic process
D	0008700	molecular_function	4-hydroxy-2-oxoglutarate aldolase activity
D	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
D	0009085	biological_process	lysine biosynthetic process
D	0009089	biological_process	lysine biosynthetic process via diaminopimelate
D	0009436	biological_process	glyoxylate catabolic process
D	0016829	molecular_function	lyase activity
D	0019877	biological_process	diaminopimelate biosynthetic process
D	0044281	biological_process	small molecule metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 301

Chain	Residue
A	GLU36
A	HOH492

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG A 302

Chain	Residue
A	ALA263
A	GLY264
A	ILE295
A	GLY297

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B 301

Chain	Residue
B	LYS166
B	HOH523
B	ALA12
B	THR47
B	THR48

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 302

Chain	Residue
B	ASN4
B	GLU160
B	HOH458

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 303

Chain	Residue
B	ASP238
B	GLU239
B	TYR241
B	ASN242
D	HIS181

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE B 304

Chain	Residue
B	GLN117
B	TYR120
B	ASP150
B	THR151
B	LYS154

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 C 301

Chain	Residue
C	GLN117
C	ASP150
C	THR151
C	LYS154
C	HOH475

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 302

Chain	Residue
C	THR73
C	VAL75
C	ASP102

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG C 304

Chain	Residue
A	ALA180
C	ASP238
C	GLU239
C	ASN242

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 D 301

Chain	Residue
D	GLN117
D	ASP150
D	THR151
D	LYS154
D	HOH518

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL D 302

Chain	Residue
D	ALA12
D	THR47
D	THR48
D	LYS166
D	HOH497

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE D 303

Chain	Residue
D	HIS223
D	PHE224
D	ASP227

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE D 304

Chain	Residue
C	ASN37
C	ASP216
D	LYS231

Functional Information from PROSITE/UniProt

site_id	PS00665
Number of Residues	18
Details	DHDPS_1 Dihydrodipicolinate synthase signature 1. AVVpvGTTGESatltheE

Chain	Residue	Details
A	ALA41-GLU58

site_id	PS00666
Number of Residues	32
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YNVPgrTgceIstdtiiklfrdcenIyGVKEA

Chain	Residue	Details
A	TYR137-ALA168

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255\|HAMAP-Rule:MF_00418

Chain	Residue	Details
A	TYR137
B	TYR137
C	TYR137
D	TYR137

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000255\|HAMAP-Rule:MF_00418

Chain	Residue	Details
A	LYS166
B	LYS166
C	LYS166
D	LYS166

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00418

Chain	Residue	Details
A	THR48
A	ILE207
B	THR48
B	ILE207
C	THR48
C	ILE207
D	THR48
D	ILE207

site_id	SWS_FT_FI4
Number of Residues	8
Details	SITE: Part of a proton relay during catalysis => ECO:0000255\|HAMAP-Rule:MF_00418

Chain	Residue	Details
A	THR47
A	TYR111
B	THR47
B	TYR111
C	THR47
C	TYR111
D	THR47
D	TYR111

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)