4R4R
Crystal structure of chimeric beta-lactamase cTEM-19m at 1.2 angstrom resolution
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 301 |
| Chain | Residue |
| A | ARG93 |
| A | LEU174 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 302 |
| Chain | Residue |
| A | GLY218 |
| A | PRO219 |
| A | LEU220 |
| A | HOH428 |
| A | HOH440 |
| A | HOH541 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 303 |
| Chain | Residue |
| A | PRO62 |
| A | GLU63 |
| A | HOH488 |
| A | HOH611 |
| A | ARG61 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 304 |
| Chain | Residue |
| A | HOH477 |
| A | HOH497 |
| A | HOH620 |
| A | HOH640 |
| A | HOH677 |
| A | HOH722 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 305 |
| Chain | Residue |
| A | ASP214 |
| A | HOH676 |
| A | HOH752 |
| A | HOH804 |
| A | HOH805 |
| A | HOH806 |
| A | HOH807 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 306 |
| Chain | Residue |
| A | HOH508 |
| A | HOH650 |
| A | HOH656 |
| A | HOH669 |
| A | HOH675 |
| A | HOH711 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 307 |
| Chain | Residue |
| A | ARG61 |
| A | HOH464 |
Functional Information from PROSITE/UniProt
| site_id | PS00146 |
| Number of Residues | 16 |
| Details | BETA_LACTAMASE_A Beta-lactamase class-A active site. FpLTSTfKvllCGAVL |
| Chain | Residue | Details |
| A | PHE66-LEU81 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 2 |
| Chain | Residue | Details |
| A | SER70 | electrostatic stabiliser |
| A | LYS73 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | SER130 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLU166 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | LYS234 | electrostatic stabiliser |
| A | ALA237 | electrostatic stabiliser, hydrogen bond donor |
