4R04
Clostridium difficile Toxin A (TcdA)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1901 |
| Chain | Residue |
| A | GLU544 |
| A | ASP545 |
| A | HIS655 |
| A | CYS700 |
| A | HIS759 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: For protease activity => ECO:0000255|PROSITE-ProRule:PRU01107, ECO:0000269|PubMed:19553670, ECO:0000269|PubMed:27571750 |
| Chain | Residue | Details |
| A | HIS655 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile; for protease activity => ECO:0000255|PROSITE-ProRule:PRU01107, ECO:0000269|PubMed:19553670, ECO:0000269|PubMed:27571750 |
| Chain | Residue | Details |
| A | CYS700 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0000269|PubMed:22747490, ECO:0000269|PubMed:28433497, ECO:0007744|PDB:3SRZ, ECO:0007744|PDB:4DMV, ECO:0007744|PDB:5UQK, ECO:0007744|PDB:5UQL |
| Chain | Residue | Details |
| A | VAL100 | |
| A | SER268 | |
| A | SER517 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0000269|PubMed:28433497, ECO:0007744|PDB:3SRZ, ECO:0007744|PDB:5UQK, ECO:0007744|PDB:5UQL |
| Chain | Residue | Details |
| A | ASN138 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0007744|PDB:3SS1 |
| Chain | Residue | Details |
| A | ASP285 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22267739, ECO:0000269|PubMed:22747490, ECO:0000269|PubMed:28433497, ECO:0007744|PDB:3SRZ, ECO:0007744|PDB:3SS1, ECO:0007744|PDB:5UQK, ECO:0007744|PDB:5UQL |
| Chain | Residue | Details |
| A | ASP287 | |
| A | GLU514 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27571750, ECO:0007744|PDB:4R04 |
| Chain | Residue | Details |
| A | GLU544 | |
| A | ASP545 | |
| A | HIS655 | |
| A | HIS759 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19553670, ECO:0007744|PDB:3HO6 |
| Chain | Residue | Details |
| A | ASN551 | |
| A | TYR579 | |
| A | LYS602 | |
| A | LYS649 | |
| A | ARG753 | |
| A | LYS766 | |
| A | LYS777 | |
| A | LYS794 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by autolysis => ECO:0000305|PubMed:19553670 |
| Chain | Residue | Details |
| A | LEU542 |
