4R04
Clostridium difficile Toxin A (TcdA)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1901 |
| Chain | Residue |
| A | GLU544 |
| A | ASP545 |
| A | HIS655 |
| A | CYS700 |
| A | HIS759 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Domain: {"description":"GT44","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 207 |
| Details | Domain: {"description":"Peptidase C80","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 372 |
| Details | Region: {"description":"Glucosyltransferase region","evidences":[{"source":"PubMed","id":"29146177","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 258 |
| Details | Region: {"description":"Autoprocessing region","evidences":[{"source":"PubMed","id":"29146177","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19553670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; for protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19553670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22267739","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22747490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DMV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22267739","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22267739","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SS1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22267739","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22747490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28433497","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R04","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19553670","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HO6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"19553670","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
