Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006979 | biological_process | response to oxidative stress |
A | 0016829 | molecular_function | lyase activity |
A | 0019172 | molecular_function | glyoxalase III activity |
A | 0019249 | biological_process | lactate biosynthetic process |
A | 0061727 | biological_process | methylglyoxal catabolic process to lactate |
A | 1903189 | biological_process | glyoxal metabolic process |
A | 1990748 | biological_process | cellular detoxification |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0006979 | biological_process | response to oxidative stress |
B | 0016829 | molecular_function | lyase activity |
B | 0019172 | molecular_function | glyoxalase III activity |
B | 0019249 | biological_process | lactate biosynthetic process |
B | 0061727 | biological_process | methylglyoxal catabolic process to lactate |
B | 1903189 | biological_process | glyoxal metabolic process |
B | 1990748 | biological_process | cellular detoxification |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005739 | cellular_component | mitochondrion |
C | 0005829 | cellular_component | cytosol |
C | 0006979 | biological_process | response to oxidative stress |
C | 0016829 | molecular_function | lyase activity |
C | 0019172 | molecular_function | glyoxalase III activity |
C | 0019249 | biological_process | lactate biosynthetic process |
C | 0061727 | biological_process | methylglyoxal catabolic process to lactate |
C | 1903189 | biological_process | glyoxal metabolic process |
C | 1990748 | biological_process | cellular detoxification |
D | 0005515 | molecular_function | protein binding |
D | 0005634 | cellular_component | nucleus |
D | 0005737 | cellular_component | cytoplasm |
D | 0005739 | cellular_component | mitochondrion |
D | 0005829 | cellular_component | cytosol |
D | 0006979 | biological_process | response to oxidative stress |
D | 0016829 | molecular_function | lyase activity |
D | 0019172 | molecular_function | glyoxalase III activity |
D | 0019249 | biological_process | lactate biosynthetic process |
D | 0061727 | biological_process | methylglyoxal catabolic process to lactate |
D | 1903189 | biological_process | glyoxal metabolic process |
D | 1990748 | biological_process | cellular detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 201 |
Chain | Residue |
A | PHE17 |
A | TRP21 |
A | SER33 |
A | MET52 |
A | TYR53 |
A | ASN55 |
B | VAL50 |
B | GLU51 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 202 |
Chain | Residue |
A | ALA64 |
A | ASP65 |
A | HOH356 |
A | HOH390 |
A | SER63 |
site_id | AC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE EDO A 203 |
Chain | Residue |
A | SER47 |
A | ARG48 |
A | GLY79 |
A | GLY80 |
A | HOH308 |
A | HOH474 |
A | HOH475 |
A | HOH509 |
B | ARG26 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 201 |
Chain | Residue |
B | HOH428 |
B | HOH489 |
B | HOH490 |
B | HOH491 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO C 201 |
Chain | Residue |
C | PHE17 |
C | TRP21 |
C | SER33 |
C | MET52 |
C | TYR53 |
C | ASN55 |
D | VAL50 |
D | GLU51 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO C 202 |
Chain | Residue |
C | GLU14 |
C | PHE17 |
C | SER18 |
C | MET46 |
C | MET52 |
C | HOH485 |
D | SER18 |
D | HOH352 |
site_id | AC7 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE EDO C 203 |
Chain | Residue |
C | SER47 |
C | ARG48 |
C | GLY79 |
C | GLY80 |
C | HOH304 |
C | HOH333 |
C | HOH459 |
C | HOH561 |
D | ARG26 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 204 |
Chain | Residue |
C | HOH445 |
C | HOH446 |
C | HOH470 |
C | HOH479 |
D | HOH344 |
D | HOH350 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG C 205 |
Chain | Residue |
A | HOH457 |
C | HOH301 |
C | HOH503 |
C | HOH504 |
C | HOH505 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG C 206 |
Chain | Residue |
B | HOH475 |
C | HOH430 |
C | HOH487 |
C | HOH517 |
site_id | BC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO D 201 |
Chain | Residue |
C | VAL50 |
C | GLU51 |
D | PHE17 |
D | TRP21 |
D | SER33 |
D | TYR53 |
D | ASN55 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO D 202 |
Chain | Residue |
C | GLY135 |
C | GLU139 |
C | HOH343 |
D | CSD111 |
D | ALA112 |
D | SER132 |
site_id | BC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG D 203 |
Chain | Residue |
B | GLU139 |
B | HOH339 |
B | HOH397 |
B | HOH398 |
D | GLY141 |
D | HOH449 |
D | HOH450 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:24758716 |
Chain | Residue | Details |
A | GLU16 | |
D | GLU16 | |
D | CSD111 | |
D | HIS130 | |
A | CSD111 | |
A | HIS130 | |
B | GLU16 | |
B | CSD111 | |
B | HIS130 | |
C | GLU16 | |
C | CSD111 | |
C | HIS130 |