4QY6
Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 301 |
| Chain | Residue |
| A | ARG93 |
| A | THR141 |
| A | LEU174 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 302 |
| Chain | Residue |
| A | SER188 |
| A | ARG191 |
| A | HOH515 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 303 |
| Chain | Residue |
| A | LYS146 |
| A | MET272 |
| A | HOH708 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 304 |
| Chain | Residue |
| A | GLY218 |
| A | PRO219 |
| A | LEU220 |
| A | HOH429 |
| A | HOH438 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 305 |
| Chain | Residue |
| A | ARG61 |
| A | PRO62 |
| A | GLU63 |
| A | HOH479 |
| A | HOH627 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 306 |
| Chain | Residue |
| A | ARG61 |
| A | HOH459 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 307 |
| Chain | Residue |
| A | ASP214 |
| A | HOH482 |
| A | HOH734 |
| A | HOH739 |
| A | HOH789 |
| A | HOH790 |
| A | HOH818 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 308 |
| Chain | Residue |
| A | HOH682 |
| A | HOH686 |
| A | HOH785 |
| A | HOH793 |
| A | HOH860 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 309 |
| Chain | Residue |
| A | HOH481 |
| A | HOH578 |
| A | HOH615 |
| A | HOH719 |
| A | HOH784 |
| A | HOH795 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 310 |
| Chain | Residue |
| A | HOH541 |
| A | HOH585 |
| A | HOH678 |
| A | HOH687 |
| A | HOH773 |
| A | HOH774 |
Functional Information from PROSITE/UniProt
| site_id | PS00146 |
| Number of Residues | 16 |
| Details | BETA_LACTAMASE_A Beta-lactamase class-A active site. FpLTSTfKvllCGAVL |
| Chain | Residue | Details |
| A | PHE66-LEU81 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 2 |
| Chain | Residue | Details |
| A | SER70 | electrostatic stabiliser |
| A | LYS73 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | SER130 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLU166 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | LYS234 | electrostatic stabiliser |
| A | ALA237 | electrostatic stabiliser, hydrogen bond donor |
