4QXB
crystal structure of histone demethylase KDM2A-H3K36ME3 with NOG
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE OGA A 600 |
| Chain | Residue |
| A | ASN142 |
| A | NI601 |
| A | HOH720 |
| A | HOH835 |
| E | M3L36 |
| A | LEU201 |
| A | THR209 |
| A | HIS212 |
| A | ASP214 |
| A | TYR222 |
| A | LYS229 |
| A | HIS284 |
| A | VAL286 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 601 |
| Chain | Residue |
| A | HIS212 |
| A | ASP214 |
| A | HIS284 |
| A | OGA600 |
| A | HOH835 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE OGA C 600 |
| Chain | Residue |
| C | ASN142 |
| C | LEU201 |
| C | THR209 |
| C | HIS212 |
| C | ASP214 |
| C | TYR222 |
| C | LYS229 |
| C | HIS284 |
| C | VAL286 |
| C | NI601 |
| C | HOH728 |
| C | HOH817 |
| F | M3L36 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI C 601 |
| Chain | Residue |
| C | HIS212 |
| C | ASP214 |
| C | HIS284 |
| C | OGA600 |
| C | HOH817 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:Q9Y2K7 |
| Chain | Residue | Details |
| B | LYS505 | |
| A | LYS229 | |
| D | LYS505 | |
| C | LYS229 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538 |
| Chain | Residue | Details |
| A | HIS212 | |
| A | ASP214 | |
| A | HIS284 | |
| C | HIS212 | |
| C | ASP214 | |
| C | HIS284 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3 |
| Chain | Residue | Details |
| E | TYR41 | |
| F | TYR41 |
