4QX7
Crystal structure of histone demethylase kdm2a-h3k36me2 with alpha-kg
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE AKG A 701 |
Chain | Residue |
A | ASN142 |
A | VAL286 |
A | NI702 |
A | HOH819 |
A | HOH832 |
E | MLY36 |
A | ILE144 |
A | LEU201 |
A | THR209 |
A | HIS212 |
A | ASP214 |
A | TYR222 |
A | LYS229 |
A | HIS284 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NI A 702 |
Chain | Residue |
A | HIS212 |
A | ASP214 |
A | TYR222 |
A | HIS284 |
A | AKG701 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE AKG C 701 |
Chain | Residue |
C | ASN142 |
C | ILE144 |
C | LEU201 |
C | THR209 |
C | HIS212 |
C | ASP214 |
C | TYR222 |
C | LYS229 |
C | HIS284 |
C | VAL286 |
C | NI702 |
C | HOH818 |
F | MLY36 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NI C 702 |
Chain | Residue |
C | HIS212 |
C | ASP214 |
C | HIS284 |
C | AKG701 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:Q9Y2K7 |
Chain | Residue | Details |
B | LYS505 | |
A | LYS229 | |
D | LYS505 | |
C | LYS229 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538 |
Chain | Residue | Details |
A | HIS212 | |
A | ASP214 | |
A | HIS284 | |
C | HIS212 | |
C | ASP214 | |
C | HIS284 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3 |
Chain | Residue | Details |
E | TYR41 | |
F | TYR41 |