4QX6
CRYSTAL STRUCTURE OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM STREPTOCOCCUS AGALACTIAE NEM316 at 2.46 ANGSTROM RESOLUTION
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006006 | biological_process | glucose metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
A | 0050661 | molecular_function | NADP binding |
A | 0051287 | molecular_function | NAD binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006006 | biological_process | glucose metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
B | 0050661 | molecular_function | NADP binding |
B | 0051287 | molecular_function | NAD binding |
C | 0000166 | molecular_function | nucleotide binding |
C | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006006 | biological_process | glucose metabolic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
C | 0050661 | molecular_function | NADP binding |
C | 0051287 | molecular_function | NAD binding |
D | 0000166 | molecular_function | nucleotide binding |
D | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006006 | biological_process | glucose metabolic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
D | 0050661 | molecular_function | NADP binding |
D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE NAD A 401 |
Chain | Residue |
A | GLY9 |
A | THR97 |
A | GLY98 |
A | THR121 |
A | ALA122 |
A | CYS152 |
A | ASN316 |
A | HOH510 |
A | HOH516 |
A | HOH517 |
A | HOH532 |
A | GLY11 |
B | PRO191 |
A | ARG12 |
A | ILE13 |
A | ASP34 |
A | LEU35 |
A | GLU77 |
A | ARG78 |
A | ALA96 |
site_id | AC2 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE NAD B 401 |
Chain | Residue |
A | PRO191 |
A | HOH504 |
B | GLY9 |
B | GLY11 |
B | ARG12 |
B | ILE13 |
B | ASN33 |
B | ASP34 |
B | LEU35 |
B | GLU77 |
B | ARG78 |
B | ALA96 |
B | THR97 |
B | GLY98 |
B | PHE99 |
B | PHE100 |
B | THR121 |
B | ALA122 |
B | CYS152 |
B | ASN316 |
B | TYR320 |
B | HOH503 |
B | HOH510 |
B | HOH523 |
site_id | AC3 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE NAD C 401 |
Chain | Residue |
C | ASN8 |
C | GLY9 |
C | GLY11 |
C | ARG12 |
C | ILE13 |
C | ASN33 |
C | ASP34 |
C | LEU35 |
C | GLU77 |
C | ARG78 |
C | ALA96 |
C | THR97 |
C | GLY98 |
C | PHE99 |
C | PHE100 |
C | THR121 |
C | ALA122 |
C | CYS152 |
C | THR182 |
C | ASN316 |
C | TYR320 |
C | EDO402 |
C | HOH508 |
D | PRO191 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE EDO C 402 |
Chain | Residue |
C | GLU95 |
C | THR97 |
C | GLY98 |
C | PHE99 |
C | PHE100 |
C | ALA101 |
C | THR121 |
C | ALA122 |
C | NAD401 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO C 403 |
Chain | Residue |
C | GLN185 |
C | MET186 |
C | ILE187 |
D | MET186 |
D | ILE187 |
site_id | AC6 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE NAD D 401 |
Chain | Residue |
D | CYS152 |
D | ASN316 |
D | TYR320 |
D | HOH506 |
D | HOH519 |
C | PRO191 |
C | HOH503 |
D | GLY9 |
D | GLY11 |
D | ARG12 |
D | ILE13 |
D | ASN33 |
D | ASP34 |
D | LEU35 |
D | GLU77 |
D | ARG78 |
D | ALA96 |
D | THR97 |
D | GLY98 |
D | PHE100 |
D | THR121 |
D | ALA122 |
Functional Information from PROSITE/UniProt
site_id | PS00071 |
Number of Residues | 8 |
Details | GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL |
Chain | Residue | Details |
A | ALA150-LEU157 |