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4QVX

Discovery of a Potent and Selective BCL-XL Inhibitor That Demonstrates Thrombocytopenia and Inhibits Tumor Growth in Vivo

Functional Information from GO Data
ChainGOidnamespacecontents
A0042981biological_processregulation of apoptotic process
B0042981biological_processregulation of apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE 3CQ A 301
ChainResidue
AALA93
ALEU130
AASP133
AASN136
AGLY138
AARG139
AARG139
AVAL141
AALA142
ASER145
APHE146
AGLU96
ATYR195
AHOH407
AHOH420
APHE97
ATYR101
AARG102
APHE105
ASER106
AASP107
ALEU108

site_idAC2
Number of Residues24
DetailsBINDING SITE FOR RESIDUE 3CQ B 301
ChainResidue
BALA93
BGLU96
BPHE97
BTYR101
BARG102
BPHE105
BSER106
BASP107
BLEU108
BTHR109
BLEU130
BARG132
BASN136
BGLY138
BARG139
BVAL141
BALA142
BSER145
BPHE146
BALA149
BTYR195
BHOH405
BHOH405
BHOH434

Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues19
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG
ChainResidueDetails
ALEU130-GLY148

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWAtFV
ChainResidueDetails
ATRP181-VAL192

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
ChainResidueDetails
AVAL86-ARG100

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsMotif: {"description":"BH3"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues38
DetailsMotif: {"description":"BH1"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues30
DetailsMotif: {"description":"BH2"}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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