4QTF

Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008360	biological_process	regulation of cell shape
A	0009252	biological_process	peptidoglycan biosynthetic process
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0018104	biological_process	peptidoglycan-protein cross-linking
A	0046872	molecular_function	metal ion binding
A	0071555	biological_process	cell wall organization
A	0071972	molecular_function	peptidoglycan L,D-transpeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MLD A 501

Chain	Residue
A	LEU62
A	THR63
A	ALA64
A	SER65
A	THR67
A	SER80
A	ARG139

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 3V5 A 502

Chain	Residue
A	GLY332
A	PHE334
A	HIS336
A	HIS352
A	GLY353
A	CYS354
A	MET303
A	SER331

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000305|PubMed:23519417

Chain	Residue	Details
A	HIS336

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000269|PubMed:23519417

Chain	Residue	Details
A	CYS354

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	ASP232
A	GLU235
A	GLY236

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site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	TYR318
A	SER331
A	ASN356

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Binds to carbapenem drug (covalent)

Chain	Residue	Details
A	CYS354

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