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4QO4

co-crystal structure of MDM2 (17-111) with compound 16, {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-(6-CYCLOPROPYLPYRIDIN-2-YL)PROPYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0043066biological_processnegative regulation of apoptotic process
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE 35S A 201
ChainResidue
ALEU54
AHIS96
AARG97
AILE99
ATYR100
AHOH303
AHOH315
AHOH323
AHOH327
AHOH345
APHE55
AGLY58
AILE61
AMET62
ATYR67
APHE86
AVAL93
ALYS94

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PDB entries from 2024-07-17

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