4QNH

Calcium-calmodulin (T79D) complexed with the calmodulin binding domain from a small conductance potassium channel SK2-a

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005516	molecular_function	calmodulin binding
B	0006813	biological_process	potassium ion transport
B	0015269	molecular_function	calcium-activated potassium channel activity
B	0016020	cellular_component	membrane
B	0016286	molecular_function	small conductance calcium-activated potassium channel activity
R	0005509	molecular_function	calcium ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 501

Chain	Residue
B	LYS451
B	HIS452
B	HOH639
B	HOH640
B	HOH663

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA R 1001

Chain	Residue
R	GLU31
R	HOH1103
R	ASP20
R	ASP22
R	ASP24
R	THR26

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA R 1002

Chain	Residue
R	ASP56
R	ASP58
R	ASN60
R	THR62
R	GLU67
R	HOH1219

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Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
R	ASP20-LEU32
R	ASP56-PHE68
R	ASP93-LEU105
R	ASP129-PHE141

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448

Chain	Residue	Details
R	ASP20
R	GLU67
R	ASP93
R	ASP95
R	ASN97
R	TYR99
R	GLU104
R	ASP129
R	ASP131
R	ASP133
R	GLN135
R	ASP22
R	GLU140
R	ASP24
R	THR26
R	GLU31
R	ASP56
R	ASP58
R	ASN60
R	THR62

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:201628, ECO:0000269|Ref.9

Chain	Residue	Details
R	ALA1

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P0DP25

Chain	Residue	Details
R	LYS21

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000269|PubMed:12392717

Chain	Residue	Details
R	THR44

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P0DP25

Chain	Residue	Details
R	SER81

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0DP25

Chain	Residue	Details
R	LYS94

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:22673903

Chain	Residue	Details
R	TYR99

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903

Chain	Residue	Details
R	SER101

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P0DP25

Chain	Residue	Details
R	THR110

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site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P0DP25

Chain	Residue	Details
R	LYS115

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site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P0DP25

Chain	Residue	Details
R	TYR138

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site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
R	LYS21

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