4QMV

MST3 IN COMPLEX WITH PF-03814735, N-{2-[(1S,4R)-6-{[4-(CYCLOBUTYLAMINO)-5-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]AMINO}-1,2,3,4-TETRAHYDRO-1,4-EPIMINONAPHTHALEN-9-YL]-2-OXOETHYL}ACETAMIDE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 34W A 401

Chain	Residue
A	GLU28
A	TYR291
A	HOH589
A	ILE30
A	VAL38
A	ALA51
A	MET99
A	GLU100
A	LEU102
A	GLY105
A	LEU151

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 402

Chain	Residue
A	LYS199
A	PRO259
A	SER260
A	HOH580

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 403

Chain	Residue
A	PRO115
A	HIS155
A	ALA213
A	ARG214
A	TYR243

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGEVFkGidnrtqkv..........VAIK

Chain	Residue	Details
A	ILE30-LYS53

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	GLY156

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	ILE42
A	GLU65
A	GLU112
A	ALA161
A	ILE174

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKA => ECO:0000269|PubMed:10644707

Chain	Residue	Details
A	ALA18

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:20124694, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	VAL190

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