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4QLE

Crystal structure of I14A DHFR mutant complexed with folate and NADP+

Functional Information from GO Data
ChainGOidnamespacecontents
A0004146molecular_functiondihydrofolate reductase activity
A0046654biological_processtetrahydrofolate biosynthetic process
A0050661molecular_functionNADP binding
B0004146molecular_functiondihydrofolate reductase activity
B0046654biological_processtetrahydrofolate biosynthetic process
B0050661molecular_functionNADP binding
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE FOL A 201
ChainResidue
AILE5
AILE94
ATYR100
ATHR113
ANAP202
AHOH301
AHOH358
AHOH387
AHOH388
AHOH410
AHOH434
AALA6
AALA7
AASP27
APHE31
ALYS32
AILE50
AARG52
AARG57

site_idAC2
Number of Residues28
DetailsBINDING SITE FOR RESIDUE NAP A 202
ChainResidue
AALA6
AALA7
AALA14
AMET16
AGLY43
AARG44
AHIS45
ATHR46
ALEU62
ASER63
ASER64
ALYS76
AILE94
AGLY96
AGLY97
AARG98
AVAL99
ATYR100
AGLN102
AFOL201
AHOH322
AHOH386
AHOH387
AHOH435
AHOH489
AHOH491
AHOH502
BHOH322

site_idAC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE FOL B 201
ChainResidue
BILE5
BALA6
BALA7
BASP27
BLEU28
BPHE31
BLYS32
BSER49
BILE50
BARG57
BILE94
BTYR100
BTHR113
BHOH302
BHOH316
BHOH330
BHOH337
BHOH417

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE NAP B 202
ChainResidue
BGLY43
BARG44
BHIS45
BTHR46
BLEU62
BSER63
BSER64
BLYS76
BGLY96
BGLY97
BARG98
BVAL99
BGLN102
BTHR123
BHOH371
BHOH379

246905

PDB entries from 2025-12-31

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