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4QJ7

Crystal structure of inactive HIV-1 protease variant (I50V/A71V) in complex with p1-p6 substrate variant (R452S)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
C0004190molecular_functionaspartic-type endopeptidase activity
C0006508biological_processproteolysis
D0004190molecular_functionaspartic-type endopeptidase activity
D0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PO4 B 101
ChainResidue
AMET36
AASN37
AHOH131
AHOH154
BGLY40
CTHR4
CHOH129

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 102
ChainResidue
BARG8
BHOH257
AHOH136
BLYS7

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 D 101
ChainResidue
CARG87
CHOH146
DLYS7
DARG8
DHOH224
DHOH252
DHOH253

site_idAC4
Number of Residues30
DetailsBINDING SITE FOR CHAIN F OF P1-P6 PEPTIDE
ChainResidue
AARG8
ALEU23
AASN25
AGLY27
AALA28
AASP29
AASP30
AILE47
AGLY48
AGLY49
AVAL82
AHOH106
AHOH140
BARG8
BLEU23
BASN25
BGLY27
BALA28
BASP29
BASP30
BLYS45
BILE47
BGLY48
BGLY49
BVAL50
BVAL82
BHOH202
BHOH253
FHOH104
FHOH105

site_idAC5
Number of Residues38
DetailsBINDING SITE FOR CHAIN G OF P1-P6 PEPTIDE
ChainResidue
AASN88
ATHR91
AGLN92
BTRP6
CARG8
CLEU23
CASN25
CGLY27
CALA28
CASP29
CVAL32
CGLY48
CGLY49
CPHE53
CILE84
CHOH113
CHOH132
DARG8
DLEU23
DASN25
DGLY27
DALA28
DASP29
DASP30
DLYS45
DMET46
DILE47
DGLY48
DGLY49
DVAL50
DVAL82
DHOH204
GHOH101
GHOH103
GHOH104
GHOH105
GHOH108
GHOH109

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage; by viral protease => ECO:0000250
ChainResidueDetails
FPHE5
GPHE5
CASN25
DASN25

site_idSWS_FT_FI2
Number of Residues4
DetailsSITE: Cleavage; by viral protease => ECO:0000250
ChainResidueDetails
APHE99
BPHE99
CPHE99
DPHE99

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PDB entries from 2024-11-06

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