Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4QH1

The GLIC pentameric Ligand-Gated Ion Channel (wild-type) in complex with bromoacetate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0071805	biological_process	potassium ion transmembrane transport
A	1902495	cellular_component	transmembrane transporter complex
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0071805	biological_process	potassium ion transmembrane transport
B	1902495	cellular_component	transmembrane transporter complex
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0071805	biological_process	potassium ion transmembrane transport
C	1902495	cellular_component	transmembrane transporter complex
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006814	biological_process	sodium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0071805	biological_process	potassium ion transmembrane transport
D	1902495	cellular_component	transmembrane transporter complex
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005267	molecular_function	potassium channel activity
E	0005272	molecular_function	sodium channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006814	biological_process	sodium ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0071805	biological_process	potassium ion transmembrane transport
E	1902495	cellular_component	transmembrane transporter complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 401

Chain	Residue
A	PHE78
A	ARG85

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BXA A 402

Chain	Residue
A	ARG77
A	ILE131
A	LEU176
A	GLU181
E	PHE42
E	ARG105

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BXA A 403

Chain	Residue
A	PRO74
A	GLU75
A	ILE76
A	ARG85
A	TYR102
A	ILE73

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 404

Chain	Residue
A	THR226
E	THR226

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR B 401

Chain	Residue
B	PHE78

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BXA B 402

Chain	Residue
A	ILE25
A	PHE42
A	ARG105
B	ARG77
B	ILE131
B	GLU181

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BXA B 403

Chain	Residue
B	PHE42
B	ARG105
C	ARG77
C	ILE131

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BXA B 404

Chain	Residue
B	PRO74
B	ILE76
B	ARG85
B	TYR102

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR C 401

Chain	Residue
C	PHE78
C	ARG85

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BXA C 402

Chain	Residue
C	ILE25
C	PHE42
C	ARG105
D	ARG77
D	ILE131
D	LEU176

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BXA C 403

Chain	Residue
C	PRO74
C	ILE76
C	ARG85
C	TYR102

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR D 401

Chain	Residue
D	PHE78
D	ARG85

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BXA D 402

Chain	Residue
D	ILE73
D	PRO74
D	GLU75
D	ILE76
D	ARG85
D	TYR102

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR E 401

Chain	Residue
E	PHE78
E	ARG85

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BXA E 402

Chain	Residue
D	ILE25
D	PHE42
D	ARG105
E	ARG77
E	VAL79
E	ILE131
E	GLU181

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BXA E 403

Chain	Residue
E	ILE73
E	PRO74
E	ILE76
E	ARG85
E	TYR102

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	990
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN2-GLN193
E	ASN245-MET252
A	ASN245-MET252
B	GLN2-GLN193
B	ASN245-MET252
C	GLN2-GLN193
C	ASN245-MET252
D	GLN2-GLN193
D	ASN245-MET252
E	GLN2-GLN193

site_id	SWS_FT_FI2
Number of Residues	530
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TYR194-PHE216
C	SER220-THR244
C	THR253-VAL281
C	PRO285-PHE317
D	TYR194-PHE216
D	SER220-THR244
D	THR253-VAL281
D	PRO285-PHE317
E	TYR194-PHE216
E	SER220-THR244
E	THR253-VAL281
A	SER220-THR244
E	PRO285-PHE317
A	THR253-VAL281
A	PRO285-PHE317
B	TYR194-PHE216
B	SER220-THR244
B	THR253-VAL281
B	PRO285-PHE317
C	TYR194-PHE216

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP217-THR219
E	GLU282-GLN284
A	GLU282-GLN284
B	TRP217-THR219
B	GLU282-GLN284
C	TRP217-THR219
C	GLU282-GLN284
D	TRP217-THR219
D	GLU282-GLN284
E	TRP217-THR219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)