4QGK

Structure of the Human Sjogren Larsson Syndrome enzyme fatty aldehyde dehydrogenase (FALDH)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004028	molecular_function	3-chloroallyl aldehyde dehydrogenase activity
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005778	cellular_component	peroxisomal membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006081	biological_process	aldehyde metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0007417	biological_process	central nervous system development
A	0007422	biological_process	peripheral nervous system development
A	0008544	biological_process	epidermis development
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0033306	biological_process	phytol metabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046458	biological_process	hexadecanal metabolic process
A	0046577	molecular_function	long-chain-alcohol oxidase activity
A	0050061	molecular_function	long-chain fatty aldehyde dehydrogenase (NAD+) activity
A	0052814	molecular_function	medium-chain fatty aldehyde dehydrogenase (NAD+) activity
A	0102673	molecular_function	fatty aldehyde dehydrogenase (NAD+) activity
A	0120553	molecular_function	farnesal dehydrogenase (NAD+) activity
B	0004028	molecular_function	3-chloroallyl aldehyde dehydrogenase activity
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005778	cellular_component	peroxisomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0006081	biological_process	aldehyde metabolic process
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0007417	biological_process	central nervous system development
B	0007422	biological_process	peripheral nervous system development
B	0008544	biological_process	epidermis development
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0033306	biological_process	phytol metabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046458	biological_process	hexadecanal metabolic process
B	0046577	molecular_function	long-chain-alcohol oxidase activity
B	0050061	molecular_function	long-chain fatty aldehyde dehydrogenase (NAD+) activity
B	0052814	molecular_function	medium-chain fatty aldehyde dehydrogenase (NAD+) activity
B	0102673	molecular_function	fatty aldehyde dehydrogenase (NAD+) activity
B	0120553	molecular_function	farnesal dehydrogenase (NAD+) activity

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. YmNCGQTCIAPD

Chain	Residue	Details
A	TYR234-ASP245

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site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP

Chain	Residue	Details
A	LEU206-PRO213

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25047030","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25047030","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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