Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4QFM

The structure of aIF2gamma subunit D152A from archaeon Sulfolobus solfataricus complexed with GDPCP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GCP A 501

Chain	Residue
A	VAL18
A	GLY96
A	ASN149
A	LYS150
A	SER184
A	ALA185
A	LEU186
A	MG502
A	FMT504
A	HOH617
A	HOH646
A	ASP19
A	HOH722
A	HOH793
A	HOH810
A	HOH811
A	HOH836
A	HOH899
A	HOH939
A	HOH940
A	HIS20
A	GLY21
A	LYS22
A	THR23
A	THR24
A	MET45
A	THR46

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 502

Chain	Residue
A	THR23
A	THR46
A	GCP501
A	HOH810
A	HOH940

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 503

Chain	Residue
A	LEU312
A	SER364
A	THR365
A	HOH745

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FMT A 504

Chain	Residue
A	VAL153
A	HIS187
A	PRO324
A	GCP501
A	HOH704
A	HOH778
A	HOH871
A	HOH899

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 505

Chain	Residue
A	GLU344
A	MET345
A	HOH757

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 506

Chain	Residue
A	ARG130
A	FMT510
A	HOH754

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 507

Chain	Residue
A	GLY258
A	LEU259
A	ARG260
A	ASN310

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 508

Chain	Residue
A	ARG88
A	HOH635
A	HOH938

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 510

Chain	Residue
A	ARG130
A	FMT506
A	HOH931

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 511

Chain	Residue
A	THR366
A	LEU367
A	ARG384

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 512

Chain	Residue
A	FMT518
A	HOH909

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 513

Chain	Residue
A	ILE32
A	ALA52
A	GLU53
A	HOH773

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 514

Chain	Residue
A	ARG384

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 515

Chain	Residue
A	GLN165
A	HOH858

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 516

Chain	Residue
A	GLU252

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 517

Chain	Residue
A	TYR68
A	ASP192
A	HOH666
A	HOH911

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 518

Chain	Residue
A	FMT512

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 519

Chain	Residue
A	HOH667
A	HOH715

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 520

Chain	Residue
A	ASP250
A	SER277
A	HOH705
A	HOH746
A	HOH791
A	HOH817

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 521

Chain	Residue
A	TRP33
A	SER35
A	GLY44
A	MET45
A	THR46
A	HOH940

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 522

Chain	Residue
A	ARG43
A	VAL99
A	HOH901

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 523

Chain	Residue
A	LYS332
A	TYR333
A	TRP410
A	HOH915

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 524

Chain	Residue
A	MET111
A	HOH726
A	HOH774
A	HOH825
A	HOH864
A	HOH894
A	HOH941

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	199
Details	Domain: {"description":"tr-type G","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"G2","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16407071","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8U082","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)