4QEP

crystal structure of KRYPTONITE in complex with mCHG DNA and SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0008270	molecular_function	zinc ion binding
A	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SAH A 801

Chain	Residue
A	LYS456
A	TYR613
A	GLY457
A	TRP458
A	TYR493
A	ARG548
A	ASN551
A	HIS552
A	TYR593
A	CYS612

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 802

Chain	Residue
A	CYS383
A	CYS397
A	CYS425
A	CYS429
A	ZN804

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 803

Chain	Residue
A	CYS389
A	CYS425
A	CYS431
A	CYS435

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 804

Chain	Residue
A	CYS383
A	CYS385
A	CYS389
A	CYS395
A	ZN802

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 805

Chain	Residue
A	CYS554
A	CYS612
A	CYS614
A	CYS619

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DLNDGRLIEsrDV

Chain	Residue	Details
A	ASP409-VAL421

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	153
Details	Domain: {"description":"YDG","evidences":[{"source":"PROSITE-ProRule","id":"PRU00358","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	62
Details	Domain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---