4QDV
Dcps in complex with covalent ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000288 | biological_process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| A | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| A | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| A | 0000932 | cellular_component | P-body |
| A | 0004532 | molecular_function | RNA exonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008380 | biological_process | RNA splicing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| A | 0110156 | biological_process | mRNA methylguanosine-cap decapping |
| A | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
| B | 0000288 | biological_process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| B | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| B | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| B | 0000932 | cellular_component | P-body |
| B | 0004532 | molecular_function | RNA exonuclease activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008380 | biological_process | RNA splicing |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| B | 0110156 | biological_process | mRNA methylguanosine-cap decapping |
| B | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
| C | 0000288 | biological_process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| C | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| C | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| C | 0000932 | cellular_component | P-body |
| C | 0004532 | molecular_function | RNA exonuclease activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005829 | cellular_component | cytosol |
| C | 0006397 | biological_process | mRNA processing |
| C | 0008380 | biological_process | RNA splicing |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| C | 0110156 | biological_process | mRNA methylguanosine-cap decapping |
| C | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
| D | 0000288 | biological_process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| D | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| D | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| D | 0000932 | cellular_component | P-body |
| D | 0004532 | molecular_function | RNA exonuclease activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005829 | cellular_component | cytosol |
| D | 0006397 | biological_process | mRNA processing |
| D | 0008380 | biological_process | RNA splicing |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| D | 0110156 | biological_process | mRNA methylguanosine-cap decapping |
| D | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 30U A 401 |
| Chain | Residue |
| A | THR130 |
| A | ILE219 |
| B | ASN110 |
| B | TYR113 |
| A | VAL132 |
| A | TYR143 |
| A | TRP175 |
| A | GLU185 |
| A | ARG188 |
| A | PRO204 |
| A | ASP205 |
| A | LEU206 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 402 |
| Chain | Residue |
| A | HIS268 |
| A | PRO271 |
| A | SER272 |
| A | TYR273 |
| A | HIS277 |
| A | HIS279 |
| A | ARG294 |
| A | PO4404 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 403 |
| Chain | Residue |
| A | HIS296 |
| A | ASN304 |
| A | HIS311 |
| A | TYR312 |
| B | GLU300 |
| B | PO4402 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 404 |
| Chain | Residue |
| A | LYS207 |
| A | HIS268 |
| A | SER272 |
| A | ARG294 |
| A | PO4402 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 401 |
| Chain | Residue |
| B | HIS268 |
| B | PRO271 |
| B | SER272 |
| B | HIS277 |
| B | HIS279 |
| B | ARG294 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 402 |
| Chain | Residue |
| A | GLU300 |
| A | PO4403 |
| B | HIS296 |
| B | ASN304 |
| B | TYR312 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 403 |
| Chain | Residue |
| B | ASP187 |
| B | ILE189 |
| B | VAL190 |
| B | ARG255 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 C 401 |
| Chain | Residue |
| C | HIS268 |
| C | PRO271 |
| C | SER272 |
| C | HIS277 |
| C | HIS279 |
| C | ARG294 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 C 402 |
| Chain | Residue |
| C | HIS296 |
| C | ASN304 |
| C | HIS311 |
| C | TYR312 |
| D | GLU300 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 30U D 401 |
| Chain | Residue |
| C | PHE108 |
| C | TYR113 |
| D | THR130 |
| D | VAL132 |
| D | TYR143 |
| D | TRP175 |
| D | GLU185 |
| D | ARG188 |
| D | PRO204 |
| D | ASP205 |
| D | LEU206 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 D 402 |
| Chain | Residue |
| D | HIS296 |
| D | ASN304 |
| D | TYR312 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 D 403 |
| Chain | Residue |
| D | HIS268 |
| D | PRO271 |
| D | SER272 |
| D | TYR273 |
| D | HIS277 |
| D | HIS279 |
| D | ARG294 |
| D | GOL404 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 404 |
| Chain | Residue |
| D | LYS207 |
| D | SER272 |
| D | ARG294 |
| D | PO4403 |
Functional Information from PROSITE/UniProt
| site_id | PS00892 |
| Number of Residues | 19 |
| Details | HIT_1 HIT domain signature. RvylhYlPsYyHLHVHFTA |
| Chain | Residue | Details |
| A | ARG264-ALA282 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| A | HIS277 | |
| B | HIS277 | |
| C | HIS277 | |
| D | HIS277 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15068804, ECO:0000269|PubMed:15769464 |
| Chain | Residue | Details |
| A | TRP175 | |
| C | GLU185 | |
| C | ASP205 | |
| C | LYS207 | |
| D | TRP175 | |
| D | GLU185 | |
| D | ASP205 | |
| D | LYS207 | |
| A | GLU185 | |
| A | ASP205 | |
| A | LYS207 | |
| B | TRP175 | |
| B | GLU185 | |
| B | ASP205 | |
| B | LYS207 | |
| C | TRP175 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS268 | |
| B | HIS268 | |
| C | HIS268 | |
| D | HIS268 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER24 | |
| B | SER24 | |
| C | SER24 | |
| D | SER24 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9DAR7 |
| Chain | Residue | Details |
| A | SER101 | |
| B | SER101 | |
| C | SER101 | |
| D | SER101 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS138 | |
| A | LYS142 | |
| B | LYS138 | |
| B | LYS142 | |
| C | LYS138 | |
| C | LYS142 | |
| D | LYS138 | |
| D | LYS142 |
