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4QBM

Crystal structure of human BAZ2A bromodomain in complex with a diacetylated histone 4 peptide (H4K16acK20ac)

Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO B 2101
ChainResidue
BGLU1803
BGLU1810
BARG1844
BARG1887
BHOH2244
BHOH2294

site_idAC2
Number of Residues30
DetailsBINDING SITE FOR CHAIN C OF GLY-ALA-LYS(AC)-AR PEPTIDE WITH SEQUENCE GLY-ALA-LYS(AC)-ARG-HIS- WITH SEQUENCE GLY-ALA-LYS(AC)-AR
ChainResidue
AARG1832
AGLN1870
ATHR1871
APHE1872
AASN1873
AGLU1874
AASP1875
AHOH2101
AHOH2103
AHOH2122
AHOH2152
AHOH2162
AHOH2173
AHOH2209
BTRP1816
BGLU1820
BLEU1826
BHOH2301
CHOH103
CHOH105
CHOH107
CHOH108
CHOH109
DGLY14
DALA15
DVAL21
DLEU22
APRO1817
AVAL1822
ASER1828

site_idAC3
Number of Residues26
DetailsBINDING SITE FOR CHAIN D OF GLY-ALA-LYS(AC)-AR PEPTIDE WITH SEQUENCE GLY-ALA-LYS(AC)-ARG-HIS- WITH SEQUENCE GLY-ALA-LYS(AC)-AR
ChainResidue
ATRP1816
ALEU1826
BTRP1816
BPHE1818
BTYR1830
BILE1833
BGLN1870
BTHR1871
BPHE1872
BASN1873
BGLU1874
BASP1875
BGLU1878
BHOH2210
BHOH2217
BHOH2237
BHOH2270
CALA15
CALY16
CALY20
CVAL21
CLEU22
DHOH101
DHOH102
DHOH104
DHOH105

Functional Information from PROSITE/UniProt
site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
CGLY14-HIS18

site_idPS00633
Number of Residues58
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFlepvNprlvs..GYRriIknpMdfstMrerllrgg..Ytsseefaadall.VfdNCqtF
ChainResidueDetails
AALA1815-PHE1872

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PDB entries from 2024-11-06

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