Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4QB9

Crystal structure of Mycobacterium smegmatis Eis in complex with paromomycin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008080	molecular_function	N-acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0030649	biological_process	aminoglycoside antibiotic catabolic process
A	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
A	0044161	cellular_component	host cell cytoplasmic vesicle
B	0008080	molecular_function	N-acetyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0030649	biological_process	aminoglycoside antibiotic catabolic process
B	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
B	0044161	cellular_component	host cell cytoplasmic vesicle
C	0008080	molecular_function	N-acetyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0030649	biological_process	aminoglycoside antibiotic catabolic process
C	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
C	0044161	cellular_component	host cell cytoplasmic vesicle
D	0008080	molecular_function	N-acetyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0030649	biological_process	aminoglycoside antibiotic catabolic process
D	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
D	0044161	cellular_component	host cell cytoplasmic vesicle
E	0008080	molecular_function	N-acetyltransferase activity
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0030649	biological_process	aminoglycoside antibiotic catabolic process
E	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
E	0044161	cellular_component	host cell cytoplasmic vesicle
F	0008080	molecular_function	N-acetyltransferase activity
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0030649	biological_process	aminoglycoside antibiotic catabolic process
F	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
F	0044161	cellular_component	host cell cytoplasmic vesicle

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PAR A 500

Chain	Residue
A	PHE26
A	TYR400
A	GLY401
A	PHE402
A	SO4501
A	SER83
A	PHE84
A	THR119
A	ALA120
A	SER121
A	GLU137
A	ASP290
A	ASP291

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	GLU137
A	GLY266
A	ASP291
A	GLU397
A	LEU398
A	PAR500

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PAR B 500

Chain	Residue
B	PHE26
B	ILE82
B	SER83
B	PHE84
B	VAL85
B	THR119
B	SER121
B	GLU137
B	ARG205
B	ASP290
B	ASP291
B	TYR400
B	GLY401
B	PHE402
B	SO4501

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 501

Chain	Residue
B	GLU137
B	GLY266
B	GLU397
B	LEU398
B	PAR500

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PAR C 500

Chain	Residue
C	PHE26
C	SER83
C	PHE84
C	THR119
C	ALA120
C	SER121
C	GLU137
C	ASP290
C	ASP291
C	TYR400
C	GLY401
C	PHE402
C	SO4501

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 501

Chain	Residue
C	GLU137
C	GLU238
C	GLY266
C	GLU397
C	LEU398
C	GLY399
C	PAR500

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PAR D 500

Chain	Residue
D	PHE26
D	SER83
D	PHE84
D	THR119
D	ALA120
D	SER121
D	GLU137
D	ASP290
D	ASP291
D	TYR400
D	GLY401
D	PHE402
D	SO4501

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 501

Chain	Residue
D	GLU137
D	VAL237
D	GLY266
D	GLU397
D	PAR500

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PAR E 500

Chain	Residue
E	PHE26
E	SER83
E	PHE84
E	VAL85
E	THR119
E	ALA120
E	SER121
E	GLU137
E	ASP290
E	ASP291
E	TYR400
E	GLY401
E	PHE402
E	SO4501

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 501

Chain	Residue
E	GLU137
E	VAL237
E	GLY266
E	GLU397
E	PAR500

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PAR F 500

Chain	Residue
F	THR119
F	ALA120
F	SER121
F	TYR126
F	GLU137
F	GLU238
F	ASP290
F	ASP291
F	GLY401
F	PHE402
F	SO4501
F	PHE26
F	SER83
F	PHE84

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 501

Chain	Residue
F	GLU137
F	GLU238
F	GLU397
F	LEU398
F	PAR500

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)