4QB8
Crystal Structure of beta-lactamase from M.tuberculosis forming Michaelis Menten with Tebipenem
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005576 | cellular_component | extracellular region |
A | 0005886 | cellular_component | plasma membrane |
A | 0008800 | molecular_function | beta-lactamase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0017001 | biological_process | antibiotic catabolic process |
A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
A | 0033250 | molecular_function | penicillinase activity |
A | 0033251 | molecular_function | cephalosporinase activity |
A | 0042597 | cellular_component | periplasmic space |
A | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PO4 A 401 |
Chain | Residue |
A | ARG79 |
A | ARG187 |
A | GLU193 |
A | ASP255 |
A | TYR286 |
A | HOH643 |
A | HOH702 |
A | HOH703 |
A | HOH798 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 A 402 |
Chain | Residue |
A | ARG53 |
A | GLN133 |
A | HOH517 |
A | HOH554 |
A | HOH591 |
A | HOH717 |
A | HOH751 |
A | HOH812 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 A 403 |
Chain | Residue |
A | ARG140 |
A | TYR141 |
A | HOH509 |
A | HOH517 |
A | HOH554 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PO4 A 404 |
Chain | Residue |
A | ARG75 |
A | GLU78 |
A | ARG115 |
A | GLU184 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 1TE A 405 |
Chain | Residue |
A | SER84 |
A | ILE117 |
A | SER142 |
A | GLU182 |
A | THR251 |
A | GLY252 |
A | THR253 |
A | HOH693 |
A | HOH699 |
A | HOH700 |
A | HOH701 |
A | HOH711 |
A | HOH796 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Acyl-ester intermediate => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112 |
Chain | Residue | Details |
A | SER84 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112 |
Chain | Residue | Details |
A | GLU182 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19251630, ECO:0000269|PubMed:20353175, ECO:0000269|PubMed:20961112 |
Chain | Residue | Details |
A | THR251 | |
A | SER142 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | SITE: Increases nucleophilicity of active site Ser => ECO:0000303|PubMed:20353175, ECO:0000303|PubMed:20961112 |
Chain | Residue | Details |
A | ALA87 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site => ECO:0000303|PubMed:24023821 |
Chain | Residue | Details |
A | ILE117 |