Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005576 | cellular_component | extracellular region |
A | 0005886 | cellular_component | plasma membrane |
A | 0008800 | molecular_function | beta-lactamase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0017001 | biological_process | antibiotic catabolic process |
A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
A | 0042597 | cellular_component | periplasmic space |
A | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TEB A 401 |
Chain | Residue |
A | CYS83 |
A | HOH618 |
A | HOH667 |
A | HOH772 |
A | SER84 |
A | LYS87 |
A | SER142 |
A | GLU182 |
A | THR232 |
A | THR251 |
A | GLY252 |
A | THR253 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 A 402 |
Chain | Residue |
A | ARG79 |
A | ARG187 |
A | GLU193 |
A | ASP255 |
A | TYR286 |
A | HOH613 |
A | HOH738 |
A | HOH813 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 A 403 |
Chain | Residue |
A | ARG75 |
A | GLU78 |
A | GLU184 |
A | HOH525 |
A | HOH533 |
A | HOH695 |
A | HOH703 |
A | HOH806 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PO4 A 404 |
Chain | Residue |
A | PRO216 |
A | ASP218 |
A | LYS219 |
A | LYS235 |
A | HOH603 |
A | HOH758 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PO4 A 405 |
Chain | Residue |
A | ARG140 |
A | TYR141 |
A | HOH590 |
Functional Information from PROSITE/UniProt
site_id | PS00146 |
Number of Residues | 16 |
Details | BETA_LACTAMASE_A Beta-lactamase class-A active site. FaFCSTfKaplVAAVL |
Chain | Residue | Details |
A | PHE80-LEU95 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | SER84 | |
Chain | Residue | Details |
A | GLU182 | |
Chain | Residue | Details |
A | SER142 | |
A | THR251 | |
Chain | Residue | Details |
A | LYS87 | |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Functions as a gatekeeper residue that regulates substrate accessibility to the enzyme active site => ECO:0000303|PubMed:24023821 |
Chain | Residue | Details |
A | ILE117 | |