4Q50
The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with 4-hydroxytamoxifen
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE OHT A 1000 |
| Chain | Residue |
| A | LEU346 |
| A | ALA350 |
| A | ASP351 |
| A | GLU353 |
| A | LEU387 |
| A | ARG394 |
| A | PHE404 |
| A | MET421 |
| A | VAL533 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OHT B 601 |
| Chain | Residue |
| B | LEU346 |
| B | ALA350 |
| B | ASP351 |
| B | GLU353 |
| B | TRP383 |
| B | LEU391 |
| B | ARG394 |
| B | MET421 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 602 |
| Chain | Residue |
| B | PRO325 |
| B | HIS356 |
| B | ASN359 |
| B | ARG363 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE OHT C 1000 |
| Chain | Residue |
| C | ALA350 |
| C | ASP351 |
| C | GLU353 |
| C | LEU384 |
| C | LEU387 |
| C | LEU391 |
| C | ARG394 |
| C | PHE404 |
| C | MET421 |
| C | ILE424 |
| C | LEU428 |
| C | LEU525 |
| C | VAL533 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OHT D 1000 |
| Chain | Residue |
| D | LEU346 |
| D | ALA350 |
| D | ASP351 |
| D | GLU353 |
| D | TRP383 |
| D | ARG394 |
| D | MET421 |
| D | LEU428 |
| D | GLY521 |
| D | LEU525 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE OHT E 1000 |
| Chain | Residue |
| E | ALA350 |
| E | ASP351 |
| E | GLU353 |
| E | ARG394 |
| E | MET421 |
| E | LEU525 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OHT F 1000 |
| Chain | Residue |
| F | MET343 |
| F | ALA350 |
| F | ASP351 |
| F | GLU353 |
| F | LEU384 |
| F | ARG394 |
| F | PHE404 |
| F | MET421 |
| F | ILE424 |
| F | LEU525 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OHT G 1000 |
| Chain | Residue |
| G | ALA350 |
| G | ASP351 |
| G | GLU353 |
| G | LEU387 |
| G | ARG394 |
| G | PHE404 |
| G | MET421 |
| G | LEU525 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE OHT H 601 |
| Chain | Residue |
| H | ALA350 |
| H | ASP351 |
| H | GLU353 |
| H | LEU387 |
| H | ARG394 |
| H | MET421 |
| H | PRO535 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 H 602 |
| Chain | Residue |
| H | PRO325 |
| H | HIS356 |
| H | ASN359 |
| H | ARG363 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
